The etiology of Parkinson's disease (PD) is still not fully clear, but several studies have implicated metals as cofactors of risk. To assess a potential]imbalance in the trace elements concentration of hair of subjects affected by PD, the content of Al, Ba, Cd, Co, Cr, Hg, Mn, Me, Ph, Sri, Sr and Zr in 81 patients affected by PD and 17 age-matched controls was determined. Quantification of the elements was performed by inductively coupled plasma mass spectrometry. Results indicated significantly lower levels of Ph in the hair of patients (p <= 0.05) compared with controls. Manganese was slightly higher while Ba, Sri and Sr levels were lower in patients, although these differences were not significant, no variations in Al, Cd, Co, Cr, Mo and Zr levels were observed in PD. Barium and Sr in hair were higher in women than in men in both controls and patients. In addition, again Ba and Sr of patients decreased with age with a p < 0.0 1 for both elements. Finally, a decreased value of Ph with the duration and the severity of the disease and Hg with the severity duration of the pathology were observed.

Forte G., Alimonti A., Violante N., Sancesario G., Brusa L., & Bocca B. (2007). Metals imbalance in hair of patients affected by Parkinson's disease. TRACE ELEMENTS AND ELECTROLYTES, 24(4), 202-210.

Metals imbalance in hair of patients affected by Parkinson's disease

SANCESARIO, GIUSEPPE;
2007

Abstract

The etiology of Parkinson's disease (PD) is still not fully clear, but several studies have implicated metals as cofactors of risk. To assess a potential]imbalance in the trace elements concentration of hair of subjects affected by PD, the content of Al, Ba, Cd, Co, Cr, Hg, Mn, Me, Ph, Sri, Sr and Zr in 81 patients affected by PD and 17 age-matched controls was determined. Quantification of the elements was performed by inductively coupled plasma mass spectrometry. Results indicated significantly lower levels of Ph in the hair of patients (p <= 0.05) compared with controls. Manganese was slightly higher while Ba, Sri and Sr levels were lower in patients, although these differences were not significant, no variations in Al, Cd, Co, Cr, Mo and Zr levels were observed in PD. Barium and Sr in hair were higher in women than in men in both controls and patients. In addition, again Ba and Sr of patients decreased with age with a p < 0.0 1 for both elements. Finally, a decreased value of Ph with the duration and the severity of the disease and Hg with the severity duration of the pathology were observed.
Pubblicato
Rilevanza internazionale
Articolo
Nessuno
Settore MED/26 - Neurologia
eng
Con Impact Factor ISI
Human hair; Inductively coupled plasma mass spectrometry; Parkinson's disease; Trace elements
Forte G., Alimonti A., Violante N., Sancesario G., Brusa L., & Bocca B. (2007). Metals imbalance in hair of patients affected by Parkinson's disease. TRACE ELEMENTS AND ELECTROLYTES, 24(4), 202-210.
Forte, G; Alimonti, A; Violante, N; Sancesario, G; Brusa, L; Bocca, B
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/36549
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