Galanin (Gal) is a neuropeptide with supposed neurotrophic-like action. In the present study, expression of Gal has been investigated in the core and peri-infarct zone at 1, 4, 24 and 72 h after middle cerebral artery occlusion (MCAo) in the rat. Three days after MCAo a small but consistent number of morphological intact Gal-positive neuronal cells were observed in the peri-infarct zone. Gal-positive cells were barely detectable in the infarct and peri-infarct zone at 24 h. No Gal immunopositive cells were detected in brain subjected to I and 4 h of ischemia. Gal immunoreactivity was also detected in myelinated fibers 4 and 24 h after focal ischemia. Gal may be a peptide with neurotrophic and plasticity functions under stress conditions. (C) 2005 Elsevier B.V. All rights reserved.

De Michele, M., Sancesario, G., Toni, D., Ciuffoli, A., Bernardi, G., Sette, G. (2006). Specific expression of galanin in the peri-infarct zone after permanent focal cerebral ischemia in the rat. REGULATORY PEPTIDES, 134(1), 38-45 [10.1016/j.regpep.2005.12.002].

Specific expression of galanin in the peri-infarct zone after permanent focal cerebral ischemia in the rat

SANCESARIO, GIUSEPPE;BERNARDI, GIORGIO;
2006-01-01

Abstract

Galanin (Gal) is a neuropeptide with supposed neurotrophic-like action. In the present study, expression of Gal has been investigated in the core and peri-infarct zone at 1, 4, 24 and 72 h after middle cerebral artery occlusion (MCAo) in the rat. Three days after MCAo a small but consistent number of morphological intact Gal-positive neuronal cells were observed in the peri-infarct zone. Gal-positive cells were barely detectable in the infarct and peri-infarct zone at 24 h. No Gal immunopositive cells were detected in brain subjected to I and 4 h of ischemia. Gal immunoreactivity was also detected in myelinated fibers 4 and 24 h after focal ischemia. Gal may be a peptide with neurotrophic and plasticity functions under stress conditions. (C) 2005 Elsevier B.V. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - Neurologia
English
Con Impact Factor ISI
Ischemia (focal); Neuroplasticity; Neurotrophic factors
De Michele, M., Sancesario, G., Toni, D., Ciuffoli, A., Bernardi, G., Sette, G. (2006). Specific expression of galanin in the peri-infarct zone after permanent focal cerebral ischemia in the rat. REGULATORY PEPTIDES, 134(1), 38-45 [10.1016/j.regpep.2005.12.002].
De Michele, M; Sancesario, G; Toni, D; Ciuffoli, A; Bernardi, G; Sette, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/36491
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