skin serves as a barrier to protect our body from injury, pathogens and trans-epidermal water loss. It is the only tissue directly exposed to oxygen besides lungs. air exposure is an essential step of in vitro generation skin graft. however, the role of oxygen in this process remains hitherto unclear. teshima et al. unveiled the impact of the hypoxia-inducible factor (HIF) pathway on epidermal differentiation in three-dimensional skin models. the authors of this work describe how air-lifting of organotypic epidermal cultures impairs HIFs activity, leading to a proper terminal differentiation of keratinocytes and stratification.
Smirnov, A., Candi, E. (2023). Take a breath: oxygen sensing of epidermal differentiation. THE FEBS JOURNAL, 290(8), 2029-2031 [10.1111/febs.16752].
Take a breath: oxygen sensing of epidermal differentiation
Smirnov A.;Candi E.
2023-01-01
Abstract
skin serves as a barrier to protect our body from injury, pathogens and trans-epidermal water loss. It is the only tissue directly exposed to oxygen besides lungs. air exposure is an essential step of in vitro generation skin graft. however, the role of oxygen in this process remains hitherto unclear. teshima et al. unveiled the impact of the hypoxia-inducible factor (HIF) pathway on epidermal differentiation in three-dimensional skin models. the authors of this work describe how air-lifting of organotypic epidermal cultures impairs HIFs activity, leading to a proper terminal differentiation of keratinocytes and stratification.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
