A Longitudinal Multiinstitutional Study of Vulvar Lichen Sclerosus: From Childhood to Perimenopause

objective: the main outcome of this study was the evaluation of clinical characteristics, comorbidities, and therapeutic approaches in patients with vulvar lichen sclerosus (VLS) aged from childhood to perimenopause. secondly, it was intended to compare these characteristics according to the menarchal status. methods: patients less than 45 years of age with a diagnosis of VLS from January 2002 to June 2022 in 10 referral centers were included in this retrospective longitudinal study. the univariate analysis compared the dependent variables according to menarchal status. results: one hundred eighty-six patients met the inclusion criteria. at diagnosis, between 25% and 40% of premenarchal patients reported signs related to subepithelial hemorrhage. a significantly greater presence of bleeding (p < .005), easy bruising (p = .028), fissures (p = .008), petechiae/splinter hemorrhages (p < .001), and bleeding/blistering or open sores (p = .011) was observed in premenarchal patients with respect to the postmenarchal group. the perineum (p = .013) and the perianal region (p < .001) were significantly more involved in the premenarchal group. topical calcineurin inhibitors were more used in the premenarchal population (p = .004), whereas vitamin e oil and moisturizers were more used in the postmenarchal population (p = .047). conclusions: vulvar lichen sclerosus is a chronic condition that can cause vulvar changes that result in severe morbidity and affects sexual function and quality of life, even before menopause. vulvar lichen sclerosus continues to be misdiagnosed in this population. this may lead to an average delay from symptom onset to diagnosis. evaluating clinical manifestations of VLS in premenarchal and postmenarchal age allowed us to find different clinical characteristics between the 2 periods suggestive of the diagnosis.