s´ezary syndrome (SS) is a rare and aggressive T-cell lymphoma with a poor prognosis in advanced stages. allogeneic hematopoietic cell transplantation (allo-HCT) offers a potential cure, but complications such as graftversus- host disease (GvHD) remain a clinical challenge. mogamulizumab, a humanized anti-CC chemokine receptor 4 (CCR4) antibody, is sometimes used as a bridge to transplantation, but its potential interactions with allo-HCT are unclear. this report describes the case of a 37-year-old man with advanced SS who received mogamulizumab therapy followed by allo-HCT from an HLA-identical sibling donor. the patient developed severe gastrointestinal acute GvHD, which was treated with steroids and infliximab. however, the condition rapidly progressed to severe intestinal symptoms and life-threatening haemorrhagic shock, ultimately resulting in the patient’s death. this case highlights a potential link between mogamulizumab and severe acute GvHD promoted by drug-induced suppression of regulatory T cells. further research is required to fully understand the interaction between mogamulizumab and allo-HCT and to determine whether it is an optimal approach as a bridge to transplant therapy. this paradigmatic case suggests the need of personalizing transplant strategies by selecting appropriate conditioning therapy and GvHD prophylaxis to minimize potential toxicity.

Trotta, G.e., Ciangola, G., Cerroni, I., Mezzanotte, V., Nunzi, A., Anemona, L., et al. (2024). Fatal acute graft-versus-host disease in Sézary Syndrome treated with Mogamulizumab and hematopoietic cell transplantation. CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 72(3), 1-3 [10.1016/j.retram.2024.103452].

Fatal acute graft-versus-host disease in Sézary Syndrome treated with Mogamulizumab and hematopoietic cell transplantation

Trotta, Gentiana Elena;Ciangola, Giulia;Cerroni, Ilaria;Mezzanotte, Valeria;Nunzi, Andrea;Anemona, Lucia;Savino, Luca;De Angelis, Gottardo;Mariotti, Benedetta;Bonanni, Fabrizio;Meddi, Elisa;Zizzari, Annagiulia;Rapisarda, Vito Mario;Mangione, Ilaria;Bruno, Antonio;Cantonetti, Maria;Venditti, Adriano;Cerretti, Raffaella
2024-04-24

Abstract

s´ezary syndrome (SS) is a rare and aggressive T-cell lymphoma with a poor prognosis in advanced stages. allogeneic hematopoietic cell transplantation (allo-HCT) offers a potential cure, but complications such as graftversus- host disease (GvHD) remain a clinical challenge. mogamulizumab, a humanized anti-CC chemokine receptor 4 (CCR4) antibody, is sometimes used as a bridge to transplantation, but its potential interactions with allo-HCT are unclear. this report describes the case of a 37-year-old man with advanced SS who received mogamulizumab therapy followed by allo-HCT from an HLA-identical sibling donor. the patient developed severe gastrointestinal acute GvHD, which was treated with steroids and infliximab. however, the condition rapidly progressed to severe intestinal symptoms and life-threatening haemorrhagic shock, ultimately resulting in the patient’s death. this case highlights a potential link between mogamulizumab and severe acute GvHD promoted by drug-induced suppression of regulatory T cells. further research is required to fully understand the interaction between mogamulizumab and allo-HCT and to determine whether it is an optimal approach as a bridge to transplant therapy. this paradigmatic case suggests the need of personalizing transplant strategies by selecting appropriate conditioning therapy and GvHD prophylaxis to minimize potential toxicity.
24-apr-2024
Pubblicato
Rilevanza internazionale
Lettera
Esperti anonimi
Settore MED/15
English
Sezary syndrome; Allogeneic hematopoietic cell transplantation; Mogamulizumab; Graft-versus-host disease; Tregs
https://doi.org/10.1016/j.retram.2024.103452
Trotta, G.e., Ciangola, G., Cerroni, I., Mezzanotte, V., Nunzi, A., Anemona, L., et al. (2024). Fatal acute graft-versus-host disease in Sézary Syndrome treated with Mogamulizumab and hematopoietic cell transplantation. CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 72(3), 1-3 [10.1016/j.retram.2024.103452].
Trotta, Ge; Ciangola, G; Cerroni, I; Mezzanotte, V; Nunzi, A; Anemona, L; Savino, L; De Angelis, G; Mariotti, B; Bonanni, F; Meddi, E; Zizzari, A; Rap...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/361864
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