Whereas experimental studies showed that in healthy trained subjects, the phosphodiesterase-5 inhibitor (PDE-5i) sildenafil improves exercise capacity in hypoxia and not in normoxia, no studies on the effects of the long half-life PDE-5i tadalafil exist. In order to evaluate whether tadalafil influences functional parameters and performance during a maximal exercise test in normoxia, we studied 14 healthy male athletes in a double-blind cross-over protocol. Each athlete performed two tests on a cycle ergometer, both after placebo or tadalafil (at therapeutic dose: 20 mg) administration. Oxygen consumption ((V) over dot O-2), blood lactate, respiratory exchange ratio, rate of perceived exertion, arterial blood pressure (BP), heart frequency (HR) and oxygen pulse ((V) over dot O-2/HR) were evaluated before exercise, at individual ventilatory and anaerobic thresholds (IVT and IAT), at (V) over dot O-2max and during recovery. Compared to placebo, a single tadalafil administration significantly reduced systolic BP before and after exercise (p < 0.05), decreased (V) over dot O-2/HR at IVT (13.3+/-1.8 vs. 14.5+/-2.1 mL.beat(-1); p = 0.03), but did not modify individual (V) over dot O-2max, IVT, or IAT. In healthy athletes, 20 mg of tadalafil does not substantially influence physical fitness-related parameters, exercise tolerance, and cardiopulmonary responses to maximal exercise in normoxia; it remains to be verified if higher doses/prolonged use influence health and/or sport performance in field conditions.

Di Luigi L., B.C. (2008). The long-acting phosphodiesterase inhibitor tadalafil does not influence athletes' VO2max, aerobic, and anaerobic thresholds in normoxia. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 29(2), 110-115 [10.1055/s-2007-965131].

The long-acting phosphodiesterase inhibitor tadalafil does not influence athletes' VO2max, aerobic, and anaerobic thresholds in normoxia

IELLAMO, FERDINANDO;
2008

Abstract

Whereas experimental studies showed that in healthy trained subjects, the phosphodiesterase-5 inhibitor (PDE-5i) sildenafil improves exercise capacity in hypoxia and not in normoxia, no studies on the effects of the long half-life PDE-5i tadalafil exist. In order to evaluate whether tadalafil influences functional parameters and performance during a maximal exercise test in normoxia, we studied 14 healthy male athletes in a double-blind cross-over protocol. Each athlete performed two tests on a cycle ergometer, both after placebo or tadalafil (at therapeutic dose: 20 mg) administration. Oxygen consumption ((V) over dot O-2), blood lactate, respiratory exchange ratio, rate of perceived exertion, arterial blood pressure (BP), heart frequency (HR) and oxygen pulse ((V) over dot O-2/HR) were evaluated before exercise, at individual ventilatory and anaerobic thresholds (IVT and IAT), at (V) over dot O-2max and during recovery. Compared to placebo, a single tadalafil administration significantly reduced systolic BP before and after exercise (p < 0.05), decreased (V) over dot O-2/HR at IVT (13.3+/-1.8 vs. 14.5+/-2.1 mL.beat(-1); p = 0.03), but did not modify individual (V) over dot O-2max, IVT, or IAT. In healthy athletes, 20 mg of tadalafil does not substantially influence physical fitness-related parameters, exercise tolerance, and cardiopulmonary responses to maximal exercise in normoxia; it remains to be verified if higher doses/prolonged use influence health and/or sport performance in field conditions.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - Medicina Interna
Settore MED/13 - Endocrinologia
English
Con Impact Factor ISI
lactic acid; placebo; tadalafil; adult; aerobic exercise; anaerobic exercise; arterial pressure; article; athlete; bicycle ergometer; clinical trial; controlled clinical trial; controlled study; crossover procedure; double blind procedure; exercise tolerance; headache; heart hemodynamics; heart rate; human; human experiment; lactate blood level; lung gas exchange; male; oxygen consumption; systolic blood pressure; Adult; Anaerobic Threshold; Carbolines; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Exercise Test; Humans; Italy; Male; Oxygen Consumption; Phosphodiesterase Inhibitors; Physical Endurance; Placebos
Di Luigi L., B.C. (2008). The long-acting phosphodiesterase inhibitor tadalafil does not influence athletes' VO2max, aerobic, and anaerobic thresholds in normoxia. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 29(2), 110-115 [10.1055/s-2007-965131].
Di Luigi, L; Baldari, C; Pigozzi, F; Emerenziani, Gp; Gallotta, Mc; Iellamo, F; Ciminelli, E; Sgro, P; Romanelli, F; Lenzi, A; Guidetti, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/36068
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