objective: the objective of this study was to assess the technical feasibility, safety, and efficacy of transperineal laser ablation (TPLA) guided by ultrasound/magnetic resonance (MR) fusion as a salvage treatment for refractory focal prostate cancer. methods: a total of five patients who had undergone radiation therapy (RT) for prostate carcinoma and biochemical recurrence, confirmed by both prostate-specific antigen (PSA) levels and MRI (3T mpMRI), were enrolled in this study. focal ablation was performed using a 1064 nm diode laser. Post-ablation follow-up was conducted for a duration of 18 months, which included regular PSA sampling, 3T mpMRI, and ultrasound/MR fusion-guided biopsies systematic and targeted at the site of the focal treatment. results: the focal ablation procedure was carried out in an outpatient setting regimen with optimal clinical and biochemical outcomes. no recurrence was detected throughout the follow-up period. conclusion: TPLA focal treatment effectively manages local recurrences of RT refractory prostate cancer without side-effects or complications. preservation of quality of life and functional outcomes, along with a >70% reduction in PSA, were achieved. advances in knowledge: our study investigated TPLA as a salvage treatment for low-risk recurrent prostate cancer after RT, demonstrating its tolerability, feasibility, and effectiveness.

Manenti, G., Nezzo, M., Ryan, C.p., Fraioli, F.r., Carreri, B., Gigliotti, P.e., et al. (2023). transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer. BJR|OPEN, 5(1) [10.1259/BJRO.20230042].

transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer

Manenti, Guglielmo;Nezzo, Marco;Fraioli, Federico Romeo;Carreri, Beatrice;Gigliotti, Paola Elda;Angeloni, Cecilia;Di Pietro, Francesca;De Angeli, Martina;Perretta, Tommaso;D'Angelillo, Rolando Maria;Garaci, Francesco Giuseppe
2023-01-01

Abstract

objective: the objective of this study was to assess the technical feasibility, safety, and efficacy of transperineal laser ablation (TPLA) guided by ultrasound/magnetic resonance (MR) fusion as a salvage treatment for refractory focal prostate cancer. methods: a total of five patients who had undergone radiation therapy (RT) for prostate carcinoma and biochemical recurrence, confirmed by both prostate-specific antigen (PSA) levels and MRI (3T mpMRI), were enrolled in this study. focal ablation was performed using a 1064 nm diode laser. Post-ablation follow-up was conducted for a duration of 18 months, which included regular PSA sampling, 3T mpMRI, and ultrasound/MR fusion-guided biopsies systematic and targeted at the site of the focal treatment. results: the focal ablation procedure was carried out in an outpatient setting regimen with optimal clinical and biochemical outcomes. no recurrence was detected throughout the follow-up period. conclusion: TPLA focal treatment effectively manages local recurrences of RT refractory prostate cancer without side-effects or complications. preservation of quality of life and functional outcomes, along with a >70% reduction in PSA, were achieved. advances in knowledge: our study investigated TPLA as a salvage treatment for low-risk recurrent prostate cancer after RT, demonstrating its tolerability, feasibility, and effectiveness.
2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/36
English
Con Impact Factor ISI
Manenti, G., Nezzo, M., Ryan, C.p., Fraioli, F.r., Carreri, B., Gigliotti, P.e., et al. (2023). transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer. BJR|OPEN, 5(1) [10.1259/BJRO.20230042].
Manenti, G; Nezzo, M; Ryan, Cp; Fraioli, Fr; Carreri, B; Gigliotti, Pe; Angeloni, C; Di Pietro, F; De Angeli, M; Perretta, T; D'Angelillo, Rm; Garaci,...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/359923
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