background: meeting the challenge of antiretroviral therapy (ART) whose efficacy can last a lifetime requires continuous updating of the virological, pharmacological, and quality of life outcomes to be pursued and a continuous review of literature data on the efficacy and tolerability of new drugs and therapeutic strategies. methods: with the aim of identifying open questions and answers about the current controversies in modern ART, we adapted the design thinking methodology to the needs of the design phase of a scientific article, involving a team of experts in HIV care. results: five main pillars of treatment success were discussed: sustained virologic suppression over time; immunological recovery; pharmacological attributes; long-term tolerability and safety of ART; and people's satisfaction and quality of life. the definition of the outcomes to be achieved in each thematic area and the tools to achieve them were reviewed and discussed. conclusions: long-term treatment success should be intended as a combination of HIV-RNA suppression, immune recovery, and high quality of life. to achieve this, the regimen should be well-tolerated, with high potency, genetic barrier, and forgiveness, and should be tailored by a person-centered perspective, based on individual needs, preferences, and therapeutic history.
Taramasso, L., Andreoni, M., Antinori, A., Bandera, A., Bonfanti, P., Bonora, S., et al. (2023). Pillars of long-term antiretroviral therapy success. PHARMACOLOGICAL RESEARCH, 196 [10.1016/j.phrs.2023.106898].
Pillars of long-term antiretroviral therapy success
Andreoni, Massimo;Esposito, Vincenzo;Perno, Carlo Federico;Santoro, Maria;Sarmati, Loredana;
2023-10-01
Abstract
background: meeting the challenge of antiretroviral therapy (ART) whose efficacy can last a lifetime requires continuous updating of the virological, pharmacological, and quality of life outcomes to be pursued and a continuous review of literature data on the efficacy and tolerability of new drugs and therapeutic strategies. methods: with the aim of identifying open questions and answers about the current controversies in modern ART, we adapted the design thinking methodology to the needs of the design phase of a scientific article, involving a team of experts in HIV care. results: five main pillars of treatment success were discussed: sustained virologic suppression over time; immunological recovery; pharmacological attributes; long-term tolerability and safety of ART; and people's satisfaction and quality of life. the definition of the outcomes to be achieved in each thematic area and the tools to achieve them were reviewed and discussed. conclusions: long-term treatment success should be intended as a combination of HIV-RNA suppression, immune recovery, and high quality of life. to achieve this, the regimen should be well-tolerated, with high potency, genetic barrier, and forgiveness, and should be tailored by a person-centered perspective, based on individual needs, preferences, and therapeutic history.File | Dimensione | Formato | |
---|---|---|---|
Pillars of long-term antiretroviral therapy success.pdf
accesso aperto
Tipologia:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
1.43 MB
Formato
Adobe PDF
|
1.43 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.