Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

Puoti, M; Lorenzini, P; Cozzi-Lepri, A; Gori, A; Mastroianni, C; Rizzardini, G; Mazzarello, G; Antinori, A; d(')Arminio Monforte, A; Girardi, E; d'Arminio Monforte, A; Andreoni, M; Angarano, G; Antinori, A; Castelli, F; Cauda, R; Di Perri, G; Galli, M; Iardino, R; Ippolito, G; Lazzarin, A; Perno, Cf; von Schloesser, F; Viale, P; Castagna, A; Ceccherini Silberstein, F; Cozzi-Lepri, A; Girardi, E; Lo Caputo, S; Mussini, C; Puoti, M; Andreoni, M; Ammassari, A; Balotta, C; Bandera, A; Bonfanti, P; Bonora, S; Borderi, M; Calcagno, A; Calza, L; Capobianchi, Mr; Castagna, A; Ceccherini-Silberstein, F; Cingolani, A; Cinque, P; De Luca, A; Di Biagio, A; Gianotti, N; Lucas, A; Guaraldi, G; Lapadula, G; Lichtner, M; Lo Caputo, S; Madeddu, G; Maggiolo, F; Marchetti, G; Marcotullio, S; Monno, L; Mussini, C; Nozza, S; Quiros Roldan, E; Rossotti, R; Rusconi, S; Santoro, M; Saracino, A; Zaccarelli, M; Fanti, I; Galli, L; Lorenzini, P; Rodano, A; Shanyinde, M; Tavelli, A; Carletti, F; Carrara, S; Di Caro, A; Graziano, S; Petrone, F; Prota, G; Quartu, S; Truffa, S; Giacometti, Ia; Costantini, A; Valeriani, C; Angarano, G; Monno, L; Santoro, C; Maggiolo, F; Suardi, C; Donati, V; Verucchi, G; Castelli, F; Minardi, C; Quirino, T; Abeli, C; Manconi, Pe; Piano, P; Cacopardo, B; Celesia, B; Vecchiet, J; Falasca, K; Sighinolfi, L; Segala, D; Mazzotta, F; Vichi, F; Cassola, G; Viscoli, C; Alessandrini, A; Bobbio, N; Mazzarello, G; Mastroianni, C; Belvisi, V; Bonfanti, P; Caramma, I; Chiodera, A; Castelli, Ap; Galli, M; Lazzarin, A; Rizzardini, G; Ridolfo, Al; Piolini, R; Castagna, A; Salpietro, S; Carenzi, L; Moioli, Mc; Tincati, C; Marchetti, G; Mussini, C; Puzzolante, C; Lapadula, G; Abrescia, N; Chirianni, A; Borgia, G; Di Martino, F; Maddaloni, L; Gentile, I; Orlando, R; Baldelli, F; Francisci, D; Parruti, G; Ursini, T; Magnani, G; Ursitti, Ma; Andreoni, M; Vullo, V; Cristaudo, A; Cingolani, A; Baldin, G; Cicalini, S; Gallo, L; Nicastri, E; Acinapura, R; Capozzi, M; Libertone, R; Savinelli, S; Latini, A; Iaiani, G; Fontanelli Sulekova, L; Cecchetto, M; Viviani, F; Mura, Ms; Madeddu, G; De Luca, A; Rossetti, B; Caramello, P; Di Perri, G; Orofino, Gc; Bonora, S; Sciandra, M; Bassetti, M; Londero, A; Pellizzer, G; Manfrin, V

doi:10.1016/j.cmi.2016.12.003

Objective: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.Methods: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.Results: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and menwho-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.Conclusions: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Puoti, M., Lorenzini, P., Cozzi-Lepri, A., Gori, A., Mastroianni, C., Rizzardini, G., et al. (2017). Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. CLINICAL MICROBIOLOGY AND INFECTION, 23(4), 267.e1-267.e4 [10.1016/j.cmi.2016.12.003].