Objective: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.Methods: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.Results: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and menwho-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.Conclusions: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Puoti, M., Lorenzini, P., Cozzi-Lepri, A., Gori, A., Mastroianni, C., Rizzardini, G., et al. (2017). Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. CLINICAL MICROBIOLOGY AND INFECTION, 23(4), 267.e1-267.e4 [10.1016/j.cmi.2016.12.003].

Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

Gori, A.;Mastroianni, C.;Andreoni, M.;Ceccherini Silberstein, F.;Andreoni, M.;Marchetti, G.;Santoro, M.;Costantini, A.;Mazzotta, F.;Mastroianni, C.;Marchetti, G.;Andreoni, M.;Vullo, V.;Cristaudo, A.;Nicastri, E.;
2017-01-01

Abstract

Objective: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.Methods: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.Results: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and menwho-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.Conclusions: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
2017
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07
English
Con Impact Factor ISI
Cirrhosis
Cohort study
Hepatitis C virus
Human immunodeficiency virus
Incidence
Puoti, M., Lorenzini, P., Cozzi-Lepri, A., Gori, A., Mastroianni, C., Rizzardini, G., et al. (2017). Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus. CLINICAL MICROBIOLOGY AND INFECTION, 23(4), 267.e1-267.e4 [10.1016/j.cmi.2016.12.003].
Puoti, M; Lorenzini, P; Cozzi-Lepri, A; Gori, A; Mastroianni, C; Rizzardini, G; Mazzarello, G; Antinori, A; d(')Arminio Monforte, A; Girardi, E; d'Arm...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/359486
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