Background Patients with type 2 diabetes mellitus are usually treated with oral antidiabetic agents but it is still not known whether these drugs have antioxidant effects in humans.Methods We studied 60 patients with type 2 diabetes mellitus, divided into three groups on the basis of hypoglycaemic treatment (Group A: metformin, Group B: glibenclamide, Group C: diet), All patients were followed for at least I year. The three subgroups had similar clinical characteristics. Twenty healthy subjects, of comparable sex and age, were enrolled as controls. In each subject, platelet production of superoxide anion (O-2(-)) elicited by collagen, was determined by lucigenin assay.Results Patients with diabetes had higher platelet O-2(-) production than controls; no correlation was observed between blood glucose and platelet production similar to that O-2(-) production. Group A patients had platelet O-2(-) of healthy subjects but lower than Group B and Group C patients.Conclusion The present findings suggest an in vivo antioxidant activity of metformin and warrant prospective studies to further explore this hypothesis. Copyright (C) 2002 John Wiley Sons, Ltd.
Gargiulo, P., Caccese, D., Pignatelli, P., Brufani, C., De Vito, F., Marino, R., et al. (2002). Metformin decreases platelet superoxide anion production in diabetic patients. DIABETES/METABOLISM RESEARCH AND REVIEWS, 18(2), 156-159 [10.1002/dmrr.282].
Metformin decreases platelet superoxide anion production in diabetic patients
De Vito F.;Sanguigni V.
2002-03-21
Abstract
Background Patients with type 2 diabetes mellitus are usually treated with oral antidiabetic agents but it is still not known whether these drugs have antioxidant effects in humans.Methods We studied 60 patients with type 2 diabetes mellitus, divided into three groups on the basis of hypoglycaemic treatment (Group A: metformin, Group B: glibenclamide, Group C: diet), All patients were followed for at least I year. The three subgroups had similar clinical characteristics. Twenty healthy subjects, of comparable sex and age, were enrolled as controls. In each subject, platelet production of superoxide anion (O-2(-)) elicited by collagen, was determined by lucigenin assay.Results Patients with diabetes had higher platelet O-2(-) production than controls; no correlation was observed between blood glucose and platelet production similar to that O-2(-) production. Group A patients had platelet O-2(-) of healthy subjects but lower than Group B and Group C patients.Conclusion The present findings suggest an in vivo antioxidant activity of metformin and warrant prospective studies to further explore this hypothesis. Copyright (C) 2002 John Wiley Sons, Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
