Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.

Cammisotto, V., Nocella, C., Bartimoccia, S., Sanguigni, V., Francomano, D., Sciarretta, S., et al. (2021). The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors. ANTIOXIDANTS, 10(2), 1-32 [10.3390/antiox10020146].

The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

VALERIO SANGUIGNI
;
Mariangela Peruzzi
;
2021-01-20

Abstract

Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.
20-gen-2021
Pubblicato
Rilevanza internazionale
Review
Sì, ma tipo non specificato
Settore MED/01
English
antioxidants; biomarkers; cardiovascular disease; oxidative stress; risk factors; supplementation
Cammisotto, V., Nocella, C., Bartimoccia, S., Sanguigni, V., Francomano, D., Sciarretta, S., et al. (2021). The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors. ANTIOXIDANTS, 10(2), 1-32 [10.3390/antiox10020146].
Cammisotto, V; Nocella, C; Bartimoccia, S; Sanguigni, V; Francomano, D; Sciarretta, S; Pastori, D; Peruzzi, M; Cavarretta, E; D’Amico, A; Castellani, V; Frati, G; Carnevale, R; Group, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/359323
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