background: autologous fat grafting (AFG) has become a commonly used procedure for breast reconstruction (BR) after cancer removal. nevertheless, oncological considerations remain for AFG after breast cancer surgery.objectives: this article aims to evaluate the oncological safety of AFG in BR and its effect on disease-free survival (DFS) and local-regional recurrences (LRR).methods: a systematic review regarding the use of AFG in BR to identify a difference in in-cidence rates of LRR and DFS between patients who had AFG and controls was performed us-ing pubmed, MEDLINE, embase, preMEDLINE, ebase, CINAHL, PsycINFO, clinicaltrials.gov, sco-pus, and cochrane databases. the protocol was developed following the preferred reporting for Items for systematic reviews-protocols (PRISMA-P) guidelines. the included studies had to match predetermined criteria according to the PICOS approach.results: a total of 11 studies were included. seven studies reported LRR, and 5 studies re-ported DFS in 5,886 patients. our systematic review showed that AFG was not associated with increased LRR and DFS. pooled hazard ratios (HRs) (95% confidence intervals [CIs]) for LRR and DFS were 1.26 (0.90-1.76) and 1.27 (0.96-1.69), respectively. conclusions: AFG can, therefore, be performed safely in BR after breast cancer. further, ran-domized controlled trials and related systematic reviews, as well as evidence-based medicine(EBM) studies of level 1, are required to consolidate the results of the studies identified in this systematic review.(c) 2022 british association of plastic, reconstructive and aesthetic surgeons. published by El-sevier Ltd. all rights reserved.

Gentile, P., Cervelli, V. (2022). Systematic review: Oncological safety of reconstruction with fat grafting in breast cancer outcomes. JOURNAL OF PLASTIC, RECONSTRUCTIVE & AESTHETIC SURGERY, 75(11) [10.1016/j.bjps.2022.08.026].

Systematic review: Oncological safety of reconstruction with fat grafting in breast cancer outcomes

Gentile, Pietro
Writing – Original Draft Preparation
;
Cervelli, Valerio
2022-11-01

Abstract

background: autologous fat grafting (AFG) has become a commonly used procedure for breast reconstruction (BR) after cancer removal. nevertheless, oncological considerations remain for AFG after breast cancer surgery.objectives: this article aims to evaluate the oncological safety of AFG in BR and its effect on disease-free survival (DFS) and local-regional recurrences (LRR).methods: a systematic review regarding the use of AFG in BR to identify a difference in in-cidence rates of LRR and DFS between patients who had AFG and controls was performed us-ing pubmed, MEDLINE, embase, preMEDLINE, ebase, CINAHL, PsycINFO, clinicaltrials.gov, sco-pus, and cochrane databases. the protocol was developed following the preferred reporting for Items for systematic reviews-protocols (PRISMA-P) guidelines. the included studies had to match predetermined criteria according to the PICOS approach.results: a total of 11 studies were included. seven studies reported LRR, and 5 studies re-ported DFS in 5,886 patients. our systematic review showed that AFG was not associated with increased LRR and DFS. pooled hazard ratios (HRs) (95% confidence intervals [CIs]) for LRR and DFS were 1.26 (0.90-1.76) and 1.27 (0.96-1.69), respectively. conclusions: AFG can, therefore, be performed safely in BR after breast cancer. further, ran-domized controlled trials and related systematic reviews, as well as evidence-based medicine(EBM) studies of level 1, are required to consolidate the results of the studies identified in this systematic review.(c) 2022 british association of plastic, reconstructive and aesthetic surgeons. published by El-sevier Ltd. all rights reserved.
nov-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/19
English
Con Impact Factor ISI
Breast cancer fat grafting
Breast reconstruction with fat grafting
Fat grafting in plastic surgery
Outcomes of breast reconstruction
Plastic surgery
Gentile, P., Cervelli, V. (2022). Systematic review: Oncological safety of reconstruction with fat grafting in breast cancer outcomes. JOURNAL OF PLASTIC, RECONSTRUCTIVE & AESTHETIC SURGERY, 75(11) [10.1016/j.bjps.2022.08.026].
Gentile, P; Cervelli, V
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Systematic fat oncological JPRAS.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Copyright dell'editore
Dimensione 851.38 kB
Formato Adobe PDF
851.38 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/359209
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact