Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-epsilon4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons.

Savettieri, G., Messina, D., Andreoli, V., Bonavita, S., Caltagirone, C., Cittadella, R., et al. (2004). Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. JOURNAL OF NEUROLOGY, 251(10), 1208-1214 [10.1007/s00415-004-0508-y].

Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis

CALTAGIRONE, CARLO;NOCENTINI, UGO;
2004-10-01

Abstract

Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-epsilon4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons.
ott-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Genetic Variation; Odds Ratio; Analysis of Variance; Sex Characteristics; Chi-Square Distribution; Humans; Apolipoproteins E; Reverse Transcriptase Polymerase Chain Reaction; Cognition Disorders; RNA, Messenger; Multiple Sclerosis; Adult; Middle Aged; Neuropsychological Tests; Female; Male
Savettieri, G., Messina, D., Andreoli, V., Bonavita, S., Caltagirone, C., Cittadella, R., et al. (2004). Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. JOURNAL OF NEUROLOGY, 251(10), 1208-1214 [10.1007/s00415-004-0508-y].
Savettieri, G; Messina, D; Andreoli, V; Bonavita, S; Caltagirone, C; Cittadella, R; Farina, D; Fazio, M; Girlanda, P; Le Pira, F; Liguori, M; Lugaresi, A; Nocentini, U; Reggio, A; Salemi, G; Tedeschi, G; Trojano, M; Valentino, P; Quattrone, A
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/35869
Citazioni
  • ???jsp.display-item.citation.pmc??? 29
  • Scopus 146
  • ???jsp.display-item.citation.isi??? 136
social impact