early-onset parkinson’s disease (EOPD) demands tailored treatments. the younger age of patients might account for a higher sensitivity to transcranial direct current stimulation (tDCS) based non-invasive neuromodulation, which may raise as an integrative therapy in the field. accordingly, here we assessed the safety and efficacy of the primary left motor cortex (M1) anodal tDCS in EOPD. ten idiopathic EOPD patients received tDCS at 2.0 mA per 20 min for 10 days within a crossover, double-blind, sham-controlled pilot study. the outcome was evaluated by measuring changes in MDS-UPDRS part III, non-motor symptoms scale (NMSS), PD-cognitive rating scale, and PD quality of Life questionnaire-39 scores. we showed that anodal but not sham tDCS significantly reduced the NMSS total and “item 2” (sleep/fatigue) scores. other parameters were not modified. no adverse events occurred. M1 anodal tDCS might thus evoke plasticity changes in cortical-subcortical circuits involved in non-motor functions, supporting the value as a therapeutic option in EOPD.

Simonetta, C., Bissacco, J., Conti, M., Bovenzi, R., Salimei, C., Cerroni, R., et al. (2024). Motor cortex transcranial direct current stimulation improves non-motor symptoms in early-onset Parkinson’s disease: a pilot study. JOURNAL OF NEURAL TRANSMISSION, 131(2), 189-193 [10.1007/s00702-023-02726-2].

Motor cortex transcranial direct current stimulation improves non-motor symptoms in early-onset Parkinson’s disease: a pilot study

Simonetta C.;Bissacco J.;Conti M.;Bovenzi R.;Salimei C.;Cerroni R.;Pierantozzi M.;Stefani A.;Mercuri N. B.;Schirinzi T.
2024-01-01

Abstract

early-onset parkinson’s disease (EOPD) demands tailored treatments. the younger age of patients might account for a higher sensitivity to transcranial direct current stimulation (tDCS) based non-invasive neuromodulation, which may raise as an integrative therapy in the field. accordingly, here we assessed the safety and efficacy of the primary left motor cortex (M1) anodal tDCS in EOPD. ten idiopathic EOPD patients received tDCS at 2.0 mA per 20 min for 10 days within a crossover, double-blind, sham-controlled pilot study. the outcome was evaluated by measuring changes in MDS-UPDRS part III, non-motor symptoms scale (NMSS), PD-cognitive rating scale, and PD quality of Life questionnaire-39 scores. we showed that anodal but not sham tDCS significantly reduced the NMSS total and “item 2” (sleep/fatigue) scores. other parameters were not modified. no adverse events occurred. M1 anodal tDCS might thus evoke plasticity changes in cortical-subcortical circuits involved in non-motor functions, supporting the value as a therapeutic option in EOPD.
2024
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26
English
Early-onset Parkinson’s disease
Non-motor symptoms
tDCS
Simonetta, C., Bissacco, J., Conti, M., Bovenzi, R., Salimei, C., Cerroni, R., et al. (2024). Motor cortex transcranial direct current stimulation improves non-motor symptoms in early-onset Parkinson’s disease: a pilot study. JOURNAL OF NEURAL TRANSMISSION, 131(2), 189-193 [10.1007/s00702-023-02726-2].
Simonetta, C; Bissacco, J; Conti, M; Bovenzi, R; Salimei, C; Cerroni, R; Pierantozzi, M; Stefani, A; Mercuri, Nb; Schirinzi, T
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
TDCs s00702-023-02726-2.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Copyright dell'editore
Dimensione 597.06 kB
Formato Adobe PDF
597.06 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/358327
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact