Amino acid ester prodrugs of the thiazolides, introduced to improve the pharmacokinetic parameters of the parent drugs, proved to be stable as their salts but were unstable at pH > 5. Although some of the instability was due to simple hydrolysis, we have found that the main end products of the degradation were peptides formed by rearrangement. These peptides were stable solids: they maintained significant antiviral activity, and in general, they showed improved pharmacokinetics (better solubility and reduced clearance) compared to the parent thiazolides. We describe the preparation and evaluation of these peptides.
Stachulski, A.v., Rossignol, J., Pate, S., Taujanskas, J., Iggo, J.a., Aerts, R., et al. (2023). Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity. ACS BIO & MED CHEM AU, 3(4), 327-334 [10.1021/acsbiomedchemau.2c00083].
Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity
Piacentini, Sara;La Frazia, Simone;
2023-08-16
Abstract
Amino acid ester prodrugs of the thiazolides, introduced to improve the pharmacokinetic parameters of the parent drugs, proved to be stable as their salts but were unstable at pH > 5. Although some of the instability was due to simple hydrolysis, we have found that the main end products of the degradation were peptides formed by rearrangement. These peptides were stable solids: they maintained significant antiviral activity, and in general, they showed improved pharmacokinetics (better solubility and reduced clearance) compared to the parent thiazolides. We describe the preparation and evaluation of these peptides.| File | Dimensione | Formato | |
|---|---|---|---|
|
stachulski-et-al-2023-thiazolide-prodrug-esters-and-derived-peptides-synthesis-and-activity.pdf
accesso aperto
Tipologia:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
3.06 MB
Formato
Adobe PDF
|
3.06 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
