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Clinical trials of monoclonal antibodies in combination with chemotherapy have reported previously unattained response rates in patients with B-cell chronic lymphocytic leukemia (B-CLL); however, the analysis of ZAP-70 protein and/or CD38 may explain better the discordant outcomes independent of treatment.

DEL POETA, G., DEL PRINCIPE, M.i., Consalvo, M., Maurillo, L., Buccisano, F., Venditti, A., et al. (2005). The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia. CANCER, 104(12), 2743-2752 [10.1002/cncr.21535].

The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia

DEL POETA, GIOVANNI;DEL PRINCIPE, MARIA ILARIA;BUCCISANO, FRANCESCO;VENDITTI, ADRIANO;BRUNO, ANTONIO;LO COCO, FRANCESCO;CANTONETTI, MARIA;AMADORI, SERGIO
2005-12-15

Abstract

Clinical trials of monoclonal antibodies in combination with chemotherapy have reported previously unattained response rates in patients with B-cell chronic lymphocytic leukemia (B-CLL); however, the analysis of ZAP-70 protein and/or CD38 may explain better the discordant outcomes independent of treatment.
15-dic-2005
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Con Impact Factor ISI
Severity of Illness Index; Probability; Vidarabine; Drug Administration Schedule; Dose-Response Relationship, Drug; Humans; Prognosis; Aged; Risk Assessment; Antibodies, Monoclonal; Gene Expression Regulation, Neoplastic; Prospective Studies; Leukemia, Lymphocytic, Chronic, B-Cell; Adult; Treatment Outcome; Antineoplastic Combined Chemotherapy Protocols; Middle Aged; Tumor Markers, Biological; Female; Male; ZAP-70 Protein-Tyrosine Kinase; Survival Analysis; Antibodies, Monoclonal, Murine-Derived
DEL POETA, G., DEL PRINCIPE, M.i., Consalvo, M., Maurillo, L., Buccisano, F., Venditti, A., et al. (2005). The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia. CANCER, 104(12), 2743-2752 [10.1002/cncr.21535].
DEL POETA, G; DEL PRINCIPE, Mi; Consalvo, M; Maurillo, L; Buccisano, F; Venditti, A; Mazzone, C; Bruno, A; Gianní, L; Capelli, G; LO COCO, F; Cantonetti, M; Gattei, V; Amadori, S
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/35629
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