The reasons why diabetic patients with microalbuminuria have marked endothelial damage (1,2) and an increased risk of atherosclerosis (3,4) are unclear. Infection with Helicobacter pylori, especially with strains carrying the cytotoxin-associated gene A (CagA), might represent a causal factor, since anti-CagA antibodies elicited by infection may cross-react with endothelial antigens (5), increasing the vascular damage associated with diabetes itself and consequent albumin leakage. Furthermore, infection might induce a persistent systemic inflammatory response, which is a recognized risk factor for atherosclerosis (6). In this study, we investigated the possible pathogenetic role of CagA-positive H. pylori strains in type 2 diabetic patients with microalbuminuria.

Pietroiusti, A., Giuliano, M., Magrini, A., Bergamaschi, A., & Galante, A. (2006). Cytotoxin-associated gene a strains of Helicobaciter pylori represent a risk factor for the development of microalbuminuria in type 2 diabetes. DIABETES CARE, 29(6), 1399-1401.

Cytotoxin-associated gene a strains of Helicobaciter pylori represent a risk factor for the development of microalbuminuria in type 2 diabetes

PIETROIUSTI, ANTONIO;MAGRINI, ANDREA;GALANTE, ALBERTO
2006

Abstract

The reasons why diabetic patients with microalbuminuria have marked endothelial damage (1,2) and an increased risk of atherosclerosis (3,4) are unclear. Infection with Helicobacter pylori, especially with strains carrying the cytotoxin-associated gene A (CagA), might represent a causal factor, since anti-CagA antibodies elicited by infection may cross-react with endothelial antigens (5), increasing the vascular damage associated with diabetes itself and consequent albumin leakage. Furthermore, infection might induce a persistent systemic inflammatory response, which is a recognized risk factor for atherosclerosis (6). In this study, we investigated the possible pathogenetic role of CagA-positive H. pylori strains in type 2 diabetic patients with microalbuminuria.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/44 - Medicina del Lavoro
eng
Con Impact Factor ISI
albumin; C reactive protein; CagA protein; hemoglobin A1c; adult; aged; article; bacterial strain; controlled study; disease course; female; Helicobacter pylori; human; major clinical study; male; microalbuminuria; multivariate analysis; non insulin dependent diabetes mellitus; pathogenesis; protein urine level; risk factor; Adult; Albuminuria; Bacterial Toxins; Body Mass Index; Diabetes Mellitus, Type 2; Female; Helicobacter pylori; Hemoglobin A, Glycosylated; Humans; Male; Middle Aged; Regression Analysis; Risk Factors; Smoking
Pietroiusti, A., Giuliano, M., Magrini, A., Bergamaschi, A., & Galante, A. (2006). Cytotoxin-associated gene a strains of Helicobaciter pylori represent a risk factor for the development of microalbuminuria in type 2 diabetes. DIABETES CARE, 29(6), 1399-1401.
Pietroiusti, A; Giuliano, M; Magrini, A; Bergamaschi, A; Galante, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/35470
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