Background: Molecular interaction Information is a key resource in modern biomedical research. Publicly available data have previously been provided in a broad array of diverse formats, making access to this very difficult. The publication and wide implementation of the Human Proteome Organisation Proteomics Standards Initiative Molecular Interactions (HUPO PSI-MI) format in 2004 was a major step towards the establishment of a single, unified format by which molecular interactions should be presented, but focused purely on protein-protein interactions. Results: The HUPO-PSI has further developed the PSI-MI XML schema to enable the description of interactions between a wider range of molecular types, for example nucleic acids, chemical entities, and molecular complexes. Extensive details about each supported molecular interaction can now be captured, including the biological role of each molecule within that interaction, detailed description of interacting domains, and the kinetic parameters of the interaction. The format is supported by data management and analysis tools and has been adopted by major interaction data providers. Additionally, a simpler, tab-delimited format MITAB2.5 has been developed for the benefit of users who require only minimal information in an easy to access configuration. Conclusion: The PSI-MI XML2.5 and MITAB2.5 formats have been jointly developed by interaction data producers and providers from both the academic and commercial sector, and are already widely implemented and well supported by an active development community. PSI-MI XML2.5 enables the description of highly detailed molecular interaction data and facilitates data exchange between databases and users without loss of information. MITAB2.5 is a simpler format appropriate for fast Perl parsing or loading into Microsoft Excel. © 2007 Kerrien et al; licensee BioMed Central Ltd.

Kerrien S., O.S. (2007). Broadening the horizon - Level 2.5 of the HUPO-PSI format for molecular interactions. BMC BIOLOGY, 5 [10.1186/1741-7007-5-44].

Broadening the horizon - Level 2.5 of the HUPO-PSI format for molecular interactions

CESARENI, GIOVANNI;
2007

Abstract

Background: Molecular interaction Information is a key resource in modern biomedical research. Publicly available data have previously been provided in a broad array of diverse formats, making access to this very difficult. The publication and wide implementation of the Human Proteome Organisation Proteomics Standards Initiative Molecular Interactions (HUPO PSI-MI) format in 2004 was a major step towards the establishment of a single, unified format by which molecular interactions should be presented, but focused purely on protein-protein interactions. Results: The HUPO-PSI has further developed the PSI-MI XML schema to enable the description of interactions between a wider range of molecular types, for example nucleic acids, chemical entities, and molecular complexes. Extensive details about each supported molecular interaction can now be captured, including the biological role of each molecule within that interaction, detailed description of interacting domains, and the kinetic parameters of the interaction. The format is supported by data management and analysis tools and has been adopted by major interaction data providers. Additionally, a simpler, tab-delimited format MITAB2.5 has been developed for the benefit of users who require only minimal information in an easy to access configuration. Conclusion: The PSI-MI XML2.5 and MITAB2.5 formats have been jointly developed by interaction data producers and providers from both the academic and commercial sector, and are already widely implemented and well supported by an active development community. PSI-MI XML2.5 enables the description of highly detailed molecular interaction data and facilitates data exchange between databases and users without loss of information. MITAB2.5 is a simpler format appropriate for fast Perl parsing or loading into Microsoft Excel. © 2007 Kerrien et al; licensee BioMed Central Ltd.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/18 - Genetica
English
Con Impact Factor ISI
chemical agent; chemical compound; nucleic acid; protein; access to information; article; automation, computers and data processing; biological activity; computer system; data analysis; data analysis software; data synthesis; health care organization; information processing; information technology; molecular computer; molecular interaction; molecular mechanics; program development; protein analysis; protein protein interaction; reference database; biology; computer graphics; computer interface; data base; methodology; natural language processing; protein database; proteomics; standard; Computational Biology; Computer Graphics; Database Management Systems; Databases, Protein; Natural Language Processing; Protein Interaction Mapping; Proteomics; User-Computer Interface
Kerrien S., O.S. (2007). Broadening the horizon - Level 2.5 of the HUPO-PSI format for molecular interactions. BMC BIOLOGY, 5 [10.1186/1741-7007-5-44].
Kerrien, S; Orchard, S; Montecchi Palazzi, L; Aranda, B; Quinn, Af; Vinod, N; Bader, Gd; Xenarios, I; Wojcik, J; Sherman, D; Tyers, M; Salama, Jj; Moore, S; Ceol, A; Chatr Aryamontri, A; Oesterheld, M; Stumpflen, V; Salwinski, L; Nerothin, J; Cerami, E; Cusick, Me; Vidal, M; Gilson, M; Armstrong, J; Woollard, P; Hogue, C; Eisenberg, D; Cesareni, G; Apweiler, R; Hermjakob, H
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/35427
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