subthalamic nucleus deep-brain stimulation (STN-DBS), in addition to a rapid improvement of parkinson's disease (PD) motor symptoms, can exert fast, local, neuromodulator activity, reducing beta-synchronous oscillations between STN and the motor cortex with possible antikinetic features. however, STN-DBS modulation of beta-band synchronization in extramotor cortical areas has been scarcely explored. for this aim, we investigated DBS-induced short-term effects on EEG-based cortical functional connectivity (FC) in beta bands in six PD patients who underwent STN-DBS within the past year. A 10 min, 64-channel EEG recording was performed twice: in DBS-OFF and 60 min after DBS activation. seven age-matched controls performed EEG recordings as the control group. a source-reconstruction method was used to identify brain-region activity. the FC was calculated using a weighted phase-lag index in beta bands. group comparisons were made using the wilcoxon test. The PD patients showed a widespread cortical hyperconnectivity in beta bands in both DBS-OFF and -ON states compared to the controls. moreover, switching on STN-DBS determined an acute reduction in beta FC, primarily involving corticocortical links of frontal, sensorimotor and limbic lobes. we hypothesize that an increase in beta-band connectivity in PD is a widespread cortical phenomenon and that STN-DBS could quickly reduce it in the cortical regions primarily involved in basal ganglia-cortical circuits.

Conti, M., Stefani, A., Bovenzi, R., Cerroni, R., Garasto, E., Placidi, F., et al. (2022). STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson's Disease. BRAIN SCIENCES, 12(12) [10.3390/brainsci12121606].

STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson's Disease

Conti, Matteo;Stefani, Alessandro;Bovenzi, Roberta;Cerroni, Rocco;Garasto, Elena;Placidi, Fabio;Liguori, Claudio;Schirinzi, Tommaso;Mercuri, Nicola B;Pierantozzi, Mariangela
2022-11-23

Abstract

subthalamic nucleus deep-brain stimulation (STN-DBS), in addition to a rapid improvement of parkinson's disease (PD) motor symptoms, can exert fast, local, neuromodulator activity, reducing beta-synchronous oscillations between STN and the motor cortex with possible antikinetic features. however, STN-DBS modulation of beta-band synchronization in extramotor cortical areas has been scarcely explored. for this aim, we investigated DBS-induced short-term effects on EEG-based cortical functional connectivity (FC) in beta bands in six PD patients who underwent STN-DBS within the past year. A 10 min, 64-channel EEG recording was performed twice: in DBS-OFF and 60 min after DBS activation. seven age-matched controls performed EEG recordings as the control group. a source-reconstruction method was used to identify brain-region activity. the FC was calculated using a weighted phase-lag index in beta bands. group comparisons were made using the wilcoxon test. The PD patients showed a widespread cortical hyperconnectivity in beta bands in both DBS-OFF and -ON states compared to the controls. moreover, switching on STN-DBS determined an acute reduction in beta FC, primarily involving corticocortical links of frontal, sensorimotor and limbic lobes. we hypothesize that an increase in beta-band connectivity in PD is a widespread cortical phenomenon and that STN-DBS could quickly reduce it in the cortical regions primarily involved in basal ganglia-cortical circuits.
23-nov-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26
English
DBS
EEG-based functional connectivity
Parkinson’s disease
Conti, M., Stefani, A., Bovenzi, R., Cerroni, R., Garasto, E., Placidi, F., et al. (2022). STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson's Disease. BRAIN SCIENCES, 12(12) [10.3390/brainsci12121606].
Conti, M; Stefani, A; Bovenzi, R; Cerroni, R; Garasto, E; Placidi, F; Liguori, C; Schirinzi, T; Mercuri, Nb; Pierantozzi, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/352843
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