background: the neutrophil/lymphocyte ratio (NLR) at baseline has been demonstrated to correlate with higher stages of disease and to be a prognostic factor in numerous cancers. however, its function as a prognostic factor for mycosis fungoides (MF) has not been yet clarified. objective: our work aimed to assess the association of the NLR with different stages of MF and to outline whether higher values of this marker are related to a more aggressive MF.methods: we retrospectively calculated the NLRs in 302 MF patients at the moment of diagnosis. the NLR was obtained using the complete blood count values.results: the median NLR among patients with early stage disease (low-grade IA-IB-IIA) was 1.88, while the median NLR for patients with high-grade MF (IIB-IIIA-IIIB) was 2.64. statistical analysis showed positive associations of advanced MF stages with NLRs higher than 2.3. conclusions: our analysis demonstrates that the NLR represents a cheap and easily available parameter functioning as a marker for advanced MF. this might guide physicians in recognizing patients with advanced stages of disease requiring a strict follow-up or an early treatment.

DI RAIMONDO, C., Lombardo, P., Tesei, C., Esposito, F., Meconi, F., Secchi, R., et al. (2023). Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Patients with Mycosis Fungoides. DIAGNOSTICS, 13(11) [10.3390/diagnostics13111979].

Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Patients with Mycosis Fungoides

Cosimo Di Raimondo;Fabiana Esposito;Federico Meconi;Roberto Secchi;Flavia Lozzi;Cecilia Angeloni;LUCA BIANCHI;
2023-01-01

Abstract

background: the neutrophil/lymphocyte ratio (NLR) at baseline has been demonstrated to correlate with higher stages of disease and to be a prognostic factor in numerous cancers. however, its function as a prognostic factor for mycosis fungoides (MF) has not been yet clarified. objective: our work aimed to assess the association of the NLR with different stages of MF and to outline whether higher values of this marker are related to a more aggressive MF.methods: we retrospectively calculated the NLRs in 302 MF patients at the moment of diagnosis. the NLR was obtained using the complete blood count values.results: the median NLR among patients with early stage disease (low-grade IA-IB-IIA) was 1.88, while the median NLR for patients with high-grade MF (IIB-IIIA-IIIB) was 2.64. statistical analysis showed positive associations of advanced MF stages with NLRs higher than 2.3. conclusions: our analysis demonstrates that the NLR represents a cheap and easily available parameter functioning as a marker for advanced MF. this might guide physicians in recognizing patients with advanced stages of disease requiring a strict follow-up or an early treatment.
2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/35
English
CTCL
NLR
lymphoma
mycosis fungoides
DI RAIMONDO, C., Lombardo, P., Tesei, C., Esposito, F., Meconi, F., Secchi, R., et al. (2023). Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Patients with Mycosis Fungoides. DIAGNOSTICS, 13(11) [10.3390/diagnostics13111979].
DI RAIMONDO, C; Lombardo, P; Tesei, C; Esposito, F; Meconi, F; Secchi, R; Lozzi, F; Monopoli, A; Grazia Narducci, M; Scala, E; Angeloni, C; De Stefano...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/351466
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