The authors present a case of pseudoglandular schwannoma with immunohistochemical findings consistent with epithelial metaplasia. Pseudoglandular schwannoma is a rare morphological variant of benign schwannoma characterized by the presence of glandlike structures lined with Schwann cells. To the best of the authors' knowledge, this is only the fifth case of pseudoglandular schwannoma reported in the literature. Clinical, imaging, and pathological findings are described. The pathological findings were consistent with a pseudoglandular schwannoma composed of typical Schwann cells arranged in an Antoni B pattern, with numerous large pseudocystic spaces. Serial immunohistochemical studies of tissue sections revealed that the cells lining the pseudoglandular spaces were not only diffusely reactive for S100 protein, but also demonstrated focal positivity for epithelial membrane antigen and cytokeratins AE1 and AE3. The particular immunohistochemical features of incompletely differentiated Schwann cells in the present case give support to the metaplastic theory of the origin of glandlike structures in benign peripheral nerve sheath tumors.

Ruggeri, F., De Cerchio, L., Bakacs, A., Orlandi, A., Lunardi, P. (2006). Pseudoglandular schwannoma of the cauda equina: Case report. JOURNAL OF NEUROSURGERY. SPINE, 5(6), 543-545 [10.3171/spi.2006.5.6.543].

Pseudoglandular schwannoma of the cauda equina: Case report

ORLANDI, AUGUSTO;LUNARDI, PIERPAOLO
2006-01-01

Abstract

The authors present a case of pseudoglandular schwannoma with immunohistochemical findings consistent with epithelial metaplasia. Pseudoglandular schwannoma is a rare morphological variant of benign schwannoma characterized by the presence of glandlike structures lined with Schwann cells. To the best of the authors' knowledge, this is only the fifth case of pseudoglandular schwannoma reported in the literature. Clinical, imaging, and pathological findings are described. The pathological findings were consistent with a pseudoglandular schwannoma composed of typical Schwann cells arranged in an Antoni B pattern, with numerous large pseudocystic spaces. Serial immunohistochemical studies of tissue sections revealed that the cells lining the pseudoglandular spaces were not only diffusely reactive for S100 protein, but also demonstrated focal positivity for epithelial membrane antigen and cytokeratins AE1 and AE3. The particular immunohistochemical features of incompletely differentiated Schwann cells in the present case give support to the metaplastic theory of the origin of glandlike structures in benign peripheral nerve sheath tumors.
2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/08 - ANATOMIA PATOLOGICA
English
Con Impact Factor ISI
peripheral nerve sheath tumor; glandular schwannoma; pseudoglandular schwannoma; divergent differentiation
Ruggeri, F., De Cerchio, L., Bakacs, A., Orlandi, A., Lunardi, P. (2006). Pseudoglandular schwannoma of the cauda equina: Case report. JOURNAL OF NEUROSURGERY. SPINE, 5(6), 543-545 [10.3171/spi.2006.5.6.543].
Ruggeri, F; De Cerchio, L; Bakacs, A; Orlandi, A; Lunardi, P
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Pseudoghiandolar.pdf

solo utenti autorizzati

Licenza: Copyright dell'editore
Dimensione 257.05 kB
Formato Adobe PDF
257.05 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/35088
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact