The regulation of dendritic cell (DC) survival is crucial for the modulation of adaptive immunity. Ceramide is a lipid mediator of the stress response, which accumulates intracellularly during DC differentiation. We found that ceramide levels are tightly regulated in human DCs and that the pharmacological inhibition of enzymes responsible for ceramide catabolism, such as ceramidases and sphingosine kinases, sensitizes DCs to ceramide-induced cell death. It is important that inhibition of sphingosine kinases, during lipopolysaccharide stimulation, causes extensive ceramide accumulation and death of DCs. These data indicate that ceramide catabolism regulates survival of human DCs and reveal novel potential targets for the pharmacological manipulation of the immune response.

Franchi, L., Malisan, F., Tomassini, B., Testi, R. (2006). Ceramide catabolism critically controls survival of human dendritic cells. JOURNAL OF LEUKOCYTE BIOLOGY, 79(1), 166-172 [10.1189/jlb.1004601].

Ceramide catabolism critically controls survival of human dendritic cells

MALISAN, FLORENCE;TESTI, ROBERTO
2006-01-01

Abstract

The regulation of dendritic cell (DC) survival is crucial for the modulation of adaptive immunity. Ceramide is a lipid mediator of the stress response, which accumulates intracellularly during DC differentiation. We found that ceramide levels are tightly regulated in human DCs and that the pharmacological inhibition of enzymes responsible for ceramide catabolism, such as ceramidases and sphingosine kinases, sensitizes DCs to ceramide-induced cell death. It is important that inhibition of sphingosine kinases, during lipopolysaccharide stimulation, causes extensive ceramide accumulation and death of DCs. These data indicate that ceramide catabolism regulates survival of human DCs and reveal novel potential targets for the pharmacological manipulation of the immune response.
2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - PATOLOGIA GENERALE
English
Con Impact Factor ISI
LPS; ceramidases; sphingosine kinases
Franchi, L., Malisan, F., Tomassini, B., Testi, R. (2006). Ceramide catabolism critically controls survival of human dendritic cells. JOURNAL OF LEUKOCYTE BIOLOGY, 79(1), 166-172 [10.1189/jlb.1004601].
Franchi, L; Malisan, F; Tomassini, B; Testi, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/35076
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