Recent reports confirm that the management of chronic anal fissure has undergone extensive re-evaluation during the past few years. This rejuvenation of interest is attributable to the application of neurochemical treatment, which has contributed to the tendency to treat the disease on an outpatient basis. The use of botulinum neurotoxin seems to be a promising and safe approach for the treatment of chronic anal fissure, particularly in patients at high risk for incontinence. Indeed, botulinum neurotoxin has been successfully used selectively to weaken the internal anal sphincter as a treatment for chronic anal fissure. It is also more efficacious than nitrate therapy, and is not related to the patient's willingness to complete treatment.

Brisinda, G., Cadeddu, F., Brandara, F., Brisinda, D., Maria, G. (2004). Treating chronic anal fissure with botulinum neurotoxin. NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 1(2), 82-89 [10.1038/ncpgasthep0048].

Treating chronic anal fissure with botulinum neurotoxin

CADEDDU, FEDERICA;
2004-12-01

Abstract

Recent reports confirm that the management of chronic anal fissure has undergone extensive re-evaluation during the past few years. This rejuvenation of interest is attributable to the application of neurochemical treatment, which has contributed to the tendency to treat the disease on an outpatient basis. The use of botulinum neurotoxin seems to be a promising and safe approach for the treatment of chronic anal fissure, particularly in patients at high risk for incontinence. Indeed, botulinum neurotoxin has been successfully used selectively to weaken the internal anal sphincter as a treatment for chronic anal fissure. It is also more efficacious than nitrate therapy, and is not related to the patient's willingness to complete treatment.
dic-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/18 - CHIRURGIA GENERALE
English
Con Impact Factor ISI
Fissure in Ano; Botulinum Toxins; Humans; Neuromuscular Agents; Chronic Disease
Brisinda, G., Cadeddu, F., Brandara, F., Brisinda, D., Maria, G. (2004). Treating chronic anal fissure with botulinum neurotoxin. NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 1(2), 82-89 [10.1038/ncpgasthep0048].
Brisinda, G; Cadeddu, F; Brandara, F; Brisinda, D; Maria, G
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/34948
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