The authors compared the efficiency of two different blood cell separators (Amicus and Cobe-Spectra) in collecting peripheral blood progenitor cells for autologous or homologous transplantation. A total number of 129 procedures were performed, 36 with Spectra, 93 with Amicus. There was no difference between Spectra and Amicus efficiencies for CD34+ cell collection (46.685% vs 46.235%; p=n.s) but the platelet efficiencies were 17.31% and 12.54% respectively (p=0.04) and, if autologous and allogeneic collections were considered separately, a marked difference resulted in allogeneic platelet efficiency between 6 Spectra and 23 Amicus procedures (26.83% vs 8.68%, p=0.0004). The authors were able to demonstrate that in 70 Amicus autologous collections there was a different platelet efficiency, if peripheral count was considered: 12 procedures performed with a platelet count > 100 x 10(9)/l had a very low efficiency (6.86%), but this value increased if platelet count lowered (13.02% if between 100 and 50 x 10(9)/l, 22.63% if between 50 and 0 x 10(9)/l, 23 and 35 procedures respectively). The study is preliminary and the number of collections is little, but the overall data suggest that Spectra (AutoPBSC, V 6.0) and Amicus separators have the same efficiency for collecting CD34+ cells while Amicus procedures have a very low platelet contamination, especially with donors.

Adorno, G., Del Proposto, G., Palombi, F., Bruno, A., Ballatore, G., Postorino, M., et al. (2004). Collection of peripheral progenitor cells: a comparison between Amicus and Cobe-Spectra blood cell separators. TRANSFUSION AND APHERESIS SCIENCE, 30(2), 131-136 [10.1016/j.transci.2003.10.007].

Collection of peripheral progenitor cells: a comparison between Amicus and Cobe-Spectra blood cell separators

ADORNO, GASPARE;BRUNO, ANTONIO;POSTORINO, MASSIMILIANO;DEL POETA, GIOVANNI;ISACCHI, GIANCARLO;AMADORI, SERGIO
2004

Abstract

The authors compared the efficiency of two different blood cell separators (Amicus and Cobe-Spectra) in collecting peripheral blood progenitor cells for autologous or homologous transplantation. A total number of 129 procedures were performed, 36 with Spectra, 93 with Amicus. There was no difference between Spectra and Amicus efficiencies for CD34+ cell collection (46.685% vs 46.235%; p=n.s) but the platelet efficiencies were 17.31% and 12.54% respectively (p=0.04) and, if autologous and allogeneic collections were considered separately, a marked difference resulted in allogeneic platelet efficiency between 6 Spectra and 23 Amicus procedures (26.83% vs 8.68%, p=0.0004). The authors were able to demonstrate that in 70 Amicus autologous collections there was a different platelet efficiency, if peripheral count was considered: 12 procedures performed with a platelet count > 100 x 10(9)/l had a very low efficiency (6.86%), but this value increased if platelet count lowered (13.02% if between 100 and 50 x 10(9)/l, 22.63% if between 50 and 0 x 10(9)/l, 23 and 35 procedures respectively). The study is preliminary and the number of collections is little, but the overall data suggest that Spectra (AutoPBSC, V 6.0) and Amicus separators have the same efficiency for collecting CD34+ cells while Amicus procedures have a very low platelet contamination, especially with donors.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/15 - Malattie del Sangue
Settore MED/05 - Patologia Clinica
English
Con Impact Factor ISI
antineoplastic agents; humans; transplantation, homologous; cell separation; transplantation, autologous; leukemia, myeloid, acute; antigens, CD34; multiple myeloma; blood platelets; blood component removal; plateletpheresis; lymphoma, non-hodgkin; stem cells; hodgkin disease; platelet count
Adorno, G., Del Proposto, G., Palombi, F., Bruno, A., Ballatore, G., Postorino, M., et al. (2004). Collection of peripheral progenitor cells: a comparison between Amicus and Cobe-Spectra blood cell separators. TRANSFUSION AND APHERESIS SCIENCE, 30(2), 131-136 [10.1016/j.transci.2003.10.007].
Adorno, G; Del Proposto, G; Palombi, F; Bruno, A; Ballatore, G; Postorino, M; Tendas, A; DEL POETA, G; Isacchi, G; Amadori, S
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/34942
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 18
social impact