Laulimalide is one of the newest naturally occurring macrolides known to act as a microtubule stabilizing agent with properties similar to Taxol. It also stands as being one of the most flexible with 18 rotatable bonds. This large number of rotatable bonds allows for approximately 3(18) potential conformers. To examine the conformational energy surface of laulimalide, we have performed an NAMFIS deconvolution analysis for laulimalide in DMSO-d(6)-. The latter has been supplemented with a post-NAMFIS energy analysis at the Becke3LYP/6-31 G* level that examines the opposing effects of internal hydrogen bonding and synpentane interactions. In this way, we have identified 15 laulimalide conformations that can be classified into 5 different families: Supine, Convex, Cobra, Stretch, and Concave motifs.
Thepchatri, P., Cicero, D.o., Monteagudo, E., Ghosh, A., Cornett, B., Weeks, E., et al. (2005). Conformations of laulimalide in DMSO-d6. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(37), 12838-12846 [10.1021/ja042890e].
Conformations of laulimalide in DMSO-d6
CICERO, DANIEL OSCAR;
2005-01-01
Abstract
Laulimalide is one of the newest naturally occurring macrolides known to act as a microtubule stabilizing agent with properties similar to Taxol. It also stands as being one of the most flexible with 18 rotatable bonds. This large number of rotatable bonds allows for approximately 3(18) potential conformers. To examine the conformational energy surface of laulimalide, we have performed an NAMFIS deconvolution analysis for laulimalide in DMSO-d(6)-. The latter has been supplemented with a post-NAMFIS energy analysis at the Becke3LYP/6-31 G* level that examines the opposing effects of internal hydrogen bonding and synpentane interactions. In this way, we have identified 15 laulimalide conformations that can be classified into 5 different families: Supine, Convex, Cobra, Stretch, and Concave motifs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
