The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade. From cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many cellular events that are vital for cell survival. Here, we provide a comprehensive catalogue of the CDK1 upstream regulators and substrates, describing how this kinase is implicated in the control of key 'cell cycle-unrelated' biological processes. Finally, we describe how deregulation of CDK1 expression and activation has been closely associated with cancer progression and drug resistance.

Massacci, G., Perfetto, L., Sacco, F. (2023). The Cyclin-dependent kinase 1: more than a cell cycle regulator. BRITISH JOURNAL OF CANCER, 129(11), 1707-1716 [10.1038/s41416-023-02468-8].

The Cyclin-dependent kinase 1: more than a cell cycle regulator

Massacci, Giorgia;Perfetto, Livia;Sacco, Francesca
2023-11-01

Abstract

The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade. From cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many cellular events that are vital for cell survival. Here, we provide a comprehensive catalogue of the CDK1 upstream regulators and substrates, describing how this kinase is implicated in the control of key 'cell cycle-unrelated' biological processes. Finally, we describe how deregulation of CDK1 expression and activation has been closely associated with cancer progression and drug resistance.
nov-2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/18
Settore BIO/10
Settore BIO/11
English
Con Impact Factor ISI
Massacci, G., Perfetto, L., Sacco, F. (2023). The Cyclin-dependent kinase 1: more than a cell cycle regulator. BRITISH JOURNAL OF CANCER, 129(11), 1707-1716 [10.1038/s41416-023-02468-8].
Massacci, G; Perfetto, L; Sacco, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/348284
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