Formamide (HCONH2) provides a chemical frame potentially affording all the monomeric components necessary for the formation of nucleic polymers. In the presence of the appropriate catalysts, and by moderate heating, formamide yields a complete set of nucleic bases, acyclonucleosides, and favors both phosphorylations and transphosphorylations. Physico-chemical conditions exist in which formamide favors the stability of the phosphoester bonds in nucleic polymers more than that of the same bonds in monomers. This property establishes 'thermodynamic niches' in which the polymeric forms are favored. The hypothesis that these specific attributes of formamide allowed the onset of prebiotic chemical equilibria capable of Darwinian evolution is discussed. © 2007 Verlag Helvetica Chimica Acta AG, Zürich.

Saladino, R., Crestini, C., Ciciriello, F., Costanzo, G., & Di Mauro, E. (2007). Formamide chemistry and the origin of informational polymers. CHEMISTRY & BIODIVERSITY, 4(4), 694-720 [10.1002/cbdv.200790059].

Formamide chemistry and the origin of informational polymers

CRESTINI, CLAUDIA;
2007

Abstract

Formamide (HCONH2) provides a chemical frame potentially affording all the monomeric components necessary for the formation of nucleic polymers. In the presence of the appropriate catalysts, and by moderate heating, formamide yields a complete set of nucleic bases, acyclonucleosides, and favors both phosphorylations and transphosphorylations. Physico-chemical conditions exist in which formamide favors the stability of the phosphoester bonds in nucleic polymers more than that of the same bonds in monomers. This property establishes 'thermodynamic niches' in which the polymeric forms are favored. The hypothesis that these specific attributes of formamide allowed the onset of prebiotic chemical equilibria capable of Darwinian evolution is discussed. © 2007 Verlag Helvetica Chimica Acta AG, Zürich.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/03 - Chimica Generale e Inorganica
English
Con Impact Factor ISI
acyclic nucleoside; adenine; cytosine; formamide; hypoxanthine; monomer; nucleic acid base; organophosphate; polymer; prebiotic agent; purine; pyrimidine; thymine; uracil; biopolymer; DNA; formamide derivative; hydrogen cyanide; isocyanic acid derivative; nucleotide; catalysis; chemical analysis; chemical bond; chemical structure; heating; molecular evolution; phosphorylation; physical chemistry; polymerization; review; structure analysis; thermodynamics; biogenesis; chemistry; conformation; Biogenesis; Biopolymers; DNA; Formamides; Hydrogen Cyanide; Isocyanates; Models, Molecular; Molecular Conformation; Nucleotides
Saladino, R., Crestini, C., Ciciriello, F., Costanzo, G., & Di Mauro, E. (2007). Formamide chemistry and the origin of informational polymers. CHEMISTRY & BIODIVERSITY, 4(4), 694-720 [10.1002/cbdv.200790059].
Saladino, R; Crestini, C; Ciciriello, F; Costanzo, G; Di Mauro, E
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/34793
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