introduction :dry eye disease (DED) is a common ocular condition with a significant impact on patients' quality of life. conventional treatments include behavioral changes, tear substitutes, and anti-inflammatory agents; however, recent advances in the understanding of DED pathogenesis have opened the way to the development of novel treatment strategies able to target several pathways involved in the onset and persistence of DED.Areas covered: Literature search was conducted on PubMed and scopus around the term 'dry eye disease' and others involving its pathophysiology and therapeutic strategy. the primary focus was on recent drugs approved by FDA or under investigation in phase 3 clinical trials. Google and ClinicalTrials.gov were used for obtaining information about the status of FDA approval and ongoing clinical trials.Expert opinion :due to its multifaced pathogenesis, DED management is often challenging, and patients' needs are frequently unmet. recently, several novel treatments have been either FDA-approved or studied in late-phase trials. These novel drugs target-specific biological components of the ocular surface and reduce inflammation and ocular pain. additionally, new drug delivery systems allow for increased bioavailability, improve effective dosing, and minimize ocular side effects. these advances in drug therapies show real promise for better management of DED patients.

Coco, G., Ambrosini, G., Poletti, S., Meliante, L.a., Taloni, A., Scorcia, V., et al. (2023). Recent advances in drug treatments for dry eye disease. EXPERT OPINION ON PHARMACOTHERAPY, 24(18), 2059-2079 [10.1080/14656566.2023.2269090].

Recent advances in drug treatments for dry eye disease

Coco, Giulia;Ambrosini, Giacomo;Poletti, Silvia;Meliante, Laura Antonia;
2023-01-01

Abstract

introduction :dry eye disease (DED) is a common ocular condition with a significant impact on patients' quality of life. conventional treatments include behavioral changes, tear substitutes, and anti-inflammatory agents; however, recent advances in the understanding of DED pathogenesis have opened the way to the development of novel treatment strategies able to target several pathways involved in the onset and persistence of DED.Areas covered: Literature search was conducted on PubMed and scopus around the term 'dry eye disease' and others involving its pathophysiology and therapeutic strategy. the primary focus was on recent drugs approved by FDA or under investigation in phase 3 clinical trials. Google and ClinicalTrials.gov were used for obtaining information about the status of FDA approval and ongoing clinical trials.Expert opinion :due to its multifaced pathogenesis, DED management is often challenging, and patients' needs are frequently unmet. recently, several novel treatments have been either FDA-approved or studied in late-phase trials. These novel drugs target-specific biological components of the ocular surface and reduce inflammation and ocular pain. additionally, new drug delivery systems allow for increased bioavailability, improve effective dosing, and minimize ocular side effects. these advances in drug therapies show real promise for better management of DED patients.
2023
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore MED/30
English
DED
Dry eye
RCT
eye drops
randomized clinical trials
treatment
Coco, G., Ambrosini, G., Poletti, S., Meliante, L.a., Taloni, A., Scorcia, V., et al. (2023). Recent advances in drug treatments for dry eye disease. EXPERT OPINION ON PHARMACOTHERAPY, 24(18), 2059-2079 [10.1080/14656566.2023.2269090].
Coco, G; Ambrosini, G; Poletti, S; Meliante, La; Taloni, A; Scorcia, V; Giannaccare, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/347331
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