Glucocorticoids (GC) are used widely for the treatment of patients with various disorders, including autoimmune diseases, allergies, and lymphoproliferative disorders. Glucocorticoid therapy is often limited by several adverse reactions associated with GC excess. Excess GC can elicit a variety of symptoms and signs, including growth retardation in children; immunosuppression; cardiovascular disorders like hypertension and atherosclerosis; osteoporosis; myopathy; and diabetes mellitus. Currently, attention is focused on oxidative stress as one of the major determinants of endothelial dysfunction and cardiovascular senescence. The main reason for all unwanted effects of GC is that dexamethasone induces the over-production of reactive oxygen species, causing dysregulation of physiological processes. Humans and animals with GC-induced hypertension exhibit reduced nitric oxide levels; patients with excess GC levels also suffer from depression as a consequence of low levels of serotonin and melatonin. The common cofactor for the production of these vasoactive molecules is tetrahydrobiopterin (BH4), which is required for nitric oxide synthesis.

Bjelakovic, G., Beninati, S., Pavlovic, D., Kocic, G., Jevtovic, T., Kamenov, B., et al. (2007). Glucocorticoids and oxidative stress. JOURNAL OF BASIC AND CLINICAL PHYSIOLOGY AND PHARMACOLOGY, 18(2), 115-127.

Glucocorticoids and oxidative stress

BENINATI, SIMONE;
2007

Abstract

Glucocorticoids (GC) are used widely for the treatment of patients with various disorders, including autoimmune diseases, allergies, and lymphoproliferative disorders. Glucocorticoid therapy is often limited by several adverse reactions associated with GC excess. Excess GC can elicit a variety of symptoms and signs, including growth retardation in children; immunosuppression; cardiovascular disorders like hypertension and atherosclerosis; osteoporosis; myopathy; and diabetes mellitus. Currently, attention is focused on oxidative stress as one of the major determinants of endothelial dysfunction and cardiovascular senescence. The main reason for all unwanted effects of GC is that dexamethasone induces the over-production of reactive oxygen species, causing dysregulation of physiological processes. Humans and animals with GC-induced hypertension exhibit reduced nitric oxide levels; patients with excess GC levels also suffer from depression as a consequence of low levels of serotonin and melatonin. The common cofactor for the production of these vasoactive molecules is tetrahydrobiopterin (BH4), which is required for nitric oxide synthesis.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/06
English
Con Impact Factor ISI
Glucocorticoids; Nitric oxide (NO); Oxidative stress; Tetrahydrobiopterin (BH4); Unwanted effects
Bjelakovic, G., Beninati, S., Pavlovic, D., Kocic, G., Jevtovic, T., Kamenov, B., et al. (2007). Glucocorticoids and oxidative stress. JOURNAL OF BASIC AND CLINICAL PHYSIOLOGY AND PHARMACOLOGY, 18(2), 115-127.
Bjelakovic, G; Beninati, S; Pavlovic, D; Kocic, G; Jevtovic, T; Kamenov, B; Saranac, L; Bjelakovic, B; Stojanovic, I; Basic, J
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/34670
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