background: since there are few prospective studies on colorectal endoscopic resection to date, we aimed to prospectively assess safety and efficacy of endoscopic resection in a cohort of Italian patients.Methods: Prospective multicentre assessment of resection of sessile polyps or non-polypoid lesions >= 10 mm in size or smaller (if depressed). outcome measures included complete excision, morbidity, mortality, and residual/recurrence at 12 months.results: overall, 1012 resections in 928 patients were analysed (62.4% sessile polyps, 28.8% laterally spreading tumours, 8.7% depressed non-polypoid lesions). Lesions were prevalent in the proximal colon. Enbloc resection was possible in 715/1012 cases (70.7%), whereas piecemeal resection was required in 297 (29.3%). Endoscopically complete excision was achieved in 866 cases (85.6%). Adverse events occurred in 83 (8.2%), and no deaths occurred. Independent predictors of 12-month residual/recurrence were the location of the lesion in the proximal colon (OR 2.22 [95% CI 1.16-4.26]; p = 0.015) and piecemeal endoscopic resection (OR 2.76 [95% CI 1.56-4.87]; p = 0.0005). Limitations of the study were: potential expertise bias, no data on eligible and potentially resectable excluded lesions, high percentage of lesions < 20 mm, follow-up limited to 1 year.conclusion: In this registry study the endoscopic resection of colorectal lesions was safe and achieved high rates of long-term endoscopic clearance. (C) 2013 editrice gastroenterologica Italiana S.r.l. published by elsevier Ltd. all rights reserved.
Cipolletta, L., Rotondano, G., Bianco, M.a., Buffoli, F., Gizzi, G., Tessari, F., et al. (2014). Endoscopic resection for superficial colorectal neoplasia in Italy: A prospective multicentre study. DIGESTIVE AND LIVER DISEASE, 46(2), 146-151 [10.1016/j.dld.2013.09.019].
Endoscopic resection for superficial colorectal neoplasia in Italy: A prospective multicentre study
Del Vecchio Blanco, G.;
2014-01-01
Abstract
background: since there are few prospective studies on colorectal endoscopic resection to date, we aimed to prospectively assess safety and efficacy of endoscopic resection in a cohort of Italian patients.Methods: Prospective multicentre assessment of resection of sessile polyps or non-polypoid lesions >= 10 mm in size or smaller (if depressed). outcome measures included complete excision, morbidity, mortality, and residual/recurrence at 12 months.results: overall, 1012 resections in 928 patients were analysed (62.4% sessile polyps, 28.8% laterally spreading tumours, 8.7% depressed non-polypoid lesions). Lesions were prevalent in the proximal colon. Enbloc resection was possible in 715/1012 cases (70.7%), whereas piecemeal resection was required in 297 (29.3%). Endoscopically complete excision was achieved in 866 cases (85.6%). Adverse events occurred in 83 (8.2%), and no deaths occurred. Independent predictors of 12-month residual/recurrence were the location of the lesion in the proximal colon (OR 2.22 [95% CI 1.16-4.26]; p = 0.015) and piecemeal endoscopic resection (OR 2.76 [95% CI 1.56-4.87]; p = 0.0005). Limitations of the study were: potential expertise bias, no data on eligible and potentially resectable excluded lesions, high percentage of lesions < 20 mm, follow-up limited to 1 year.conclusion: In this registry study the endoscopic resection of colorectal lesions was safe and achieved high rates of long-term endoscopic clearance. (C) 2013 editrice gastroenterologica Italiana S.r.l. published by elsevier Ltd. all rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.