Antifungal agents have greatly contributed to the improvement of public health. Nevertheless, antifungal resistant pathogens have increased during the past decade, becoming a serious concern. Candida albicans has been the most extensively studied pathogen in antifungal resistance because of their morbidity and mortality associated with infections in immunocompromised patients. This review describes the antifungal mechanims of the azole fluconazole widely used for the prophylaxis and treatment of candidal infections. The specific molecular pathways occurring in fluconazole-resistance of C. albicans and some issues about new antifungal agents are also discussed.

Casalinuovo I.A., D.F.P. (2004). Fluconazole resistance in Candida albicans: A review of mechanisms. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 8(2), 69-77.

Fluconazole resistance in Candida albicans: A review of mechanisms

CASALINUOVO, IDA ANTONIA;GARACI, ENRICO
2004

Abstract

Antifungal agents have greatly contributed to the improvement of public health. Nevertheless, antifungal resistant pathogens have increased during the past decade, becoming a serious concern. Candida albicans has been the most extensively studied pathogen in antifungal resistance because of their morbidity and mortality associated with infections in immunocompromised patients. This review describes the antifungal mechanims of the azole fluconazole widely used for the prophylaxis and treatment of candidal infections. The specific molecular pathways occurring in fluconazole-resistance of C. albicans and some issues about new antifungal agents are also discussed.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
eng
Con Impact Factor ISI
Antifungal resistance; Candida albicans; Ergosterol; Fluconazole
PMID: 15267120
Casalinuovo I.A., D.F.P. (2004). Fluconazole resistance in Candida albicans: A review of mechanisms. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 8(2), 69-77.
Casalinuovo, Ia; Di Francesco, P; Garaci, E
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/34480
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