We estimate parameters of a general isolation-with-migration model using resequence data from mitochondrial DNA (mtDNA), the Y chromosome, and two loci on the X chromosome in samples of 25-50 individuals from each of 10 human populations. Application of a coalescent-based Markov chain Monte Carlo technique allows simultaneous inference of divergence times, rates of gene flow, as well as changes in effective population size. Results from comparisons between sub-Saharan African and Eurasian populations estimate that 1500 individuals founded the ancestral Eurasian population similar to 40 thousand years ago (KYA). Furthermore, these small Eurasian founding populations appear to have grown much more dramatically than either African or Oceanian populations. Analyses of sub-Saharan African populations provide little evidence for a history, of population bottlenecks and suggest that die), began diverging from one another upward of 50 KYA. We surmise that ancestral African populations had already been geographically structured prior to the founding of ancestral Eurasian populations. African populations are shown to experience low levels of mitochondrial DNA gene flow, but high levels of Y chromosome gene flow. In particular, Y chromosome gene flow appears to be asymmetric, i.e., from the Bantu-speaking population into other African populations. Conversely, mitochondrial gene flow is more extensive between non-African populations, but appears to be absent between European and Asian Populations.
Garrigan, D., Kingan, S.B., Pilkington, M.M., Wilder, J.A., Cox, M.P., Soodyall, H., et al. (2007). Inferring human population sizes, divergence times and rates of gene flow from mitochondrial, X and Y chromosome resequencing data. GENETICS, 177(4), 2195-2207.
|Tipologia:||Articolo su rivista|
|Citazione:||Garrigan, D., Kingan, S.B., Pilkington, M.M., Wilder, J.A., Cox, M.P., Soodyall, H., et al. (2007). Inferring human population sizes, divergence times and rates of gene flow from mitochondrial, X and Y chromosome resequencing data. GENETICS, 177(4), 2195-2207.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore BIO/18 - Genetica|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1534/genetics.107.077495|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||gen-2007|
|Titolo:||Inferring human population sizes, divergence times and rates of gene flow from mitochondrial, X and Y chromosome resequencing data|
|Autori:||Garrigan, D; Kingan, SB; Pilkington, MM; Wilder, JA; Cox, MP; Soodyall, H; Strassmann, B; Destro-Bisol, G; De Knijff, P; Novelletto, A; Friedlaender, J; Hammer, MF|
|Appare nelle tipologie:||01 - Articolo su rivista|