Objectives: To compare biochemical and clinical parameters in a case of fatal severe traumatic brain injury (TBI) with secondary insult. Design and methods: A TBI patient was catheterized for intracranial pressure (ICP) monitoring and cerebrospinal fluid (CSF) analysis of ascorbate, malondialdehyde, oxypurines, and nucleosides. Results: Oxidative brain damage preceded ATP catabolite increment in the CSF even with ICP below 20 mm Hg. Sustained oxidative stress caused irreversible energy state derangement followed by a refractory ICP rise. Massive oxypurine and nucleoside release was recorded 36 h before brain death. Conclusions: Molecular events, detected by biochemical CSF analysis and preceding modification of clinical parameters in severe TBI with secondary insult, are discussed. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved.
Cristofori L., T.B. (2005). Biochemical analysis of the cerebrospinal fluid: evidence for catastrophic energy failure and oxidative damage preceding brain death in severe head injury: a case report. CLINICAL BIOCHEMISTRY, 38(1), 97-100.
Tipologia: | Articolo su rivista |
Citazione: | Cristofori L., T.B. (2005). Biochemical analysis of the cerebrospinal fluid: evidence for catastrophic energy failure and oxidative damage preceding brain death in severe head injury: a case report. CLINICAL BIOCHEMISTRY, 38(1), 97-100. |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/27 - Neurochirurgia |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.clinbiochem.2004.09.013 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2005 |
Titolo: | Biochemical analysis of the cerebrospinal fluid: evidence for catastrophic energy failure and oxidative damage preceding brain death in severe head injury: a case report |
Autori: | |
Autori: | Cristofori L., Tavazzi B., Gambin R., Vagnozzi R., Signoretti S., Amorini A.M., Fazzina G., Lazzarino G. |
Appare nelle tipologie: | 01 - Articolo su rivista |