Abstract Nuclear factor-kB (NF-kB) transcription factors and the IkB kinases (IKKs) that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kB signaling also has a critical role in cancer development and progression. The canonical NF-kB pathway contributes to squamous cell carcinoma (SCC) development by interacting with other signaling pathways including tumor suppressive and oncogenic pathways in a tissue specific manner. In this chapter, we will summarize recent advances in the understanding of interconnections between NF-kB and IKKs, including IKKa which has NF-Kb independent functions, in the context of SCC development and progression and as potential target for novel chemotherapy approaches.
Costanzo, A., Spallone, G., Karin, M. (2010). NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas. In Adam B. Glick, Carter Van Waes (a cura di), Signaling Pathways in Squamous Cancer (pp. 201-222). Springer [10.1007/978-1-4419-7203-3].
NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas
COSTANZO, ANTONIO;SPALLONE, GIULIA;
2010-01-01
Abstract
Abstract Nuclear factor-kB (NF-kB) transcription factors and the IkB kinases (IKKs) that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kB signaling also has a critical role in cancer development and progression. The canonical NF-kB pathway contributes to squamous cell carcinoma (SCC) development by interacting with other signaling pathways including tumor suppressive and oncogenic pathways in a tissue specific manner. In this chapter, we will summarize recent advances in the understanding of interconnections between NF-kB and IKKs, including IKKa which has NF-Kb independent functions, in the context of SCC development and progression and as potential target for novel chemotherapy approaches.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
