gastrointestinal (GI) cancers are the most frequent neoplasm, responsible for half of all cancer-related deaths. Mmtastasis is the leading cause of death from GI cancer; thus, studying the processes that regulate cancer cell migration is of paramount importance for the development of new therapeutic strategies. In this review, we summarize the mechanisms adopted by cancer cells to promote cell migration and the subsequent metastasis formation by highlighting the key role that tumor microenvironment components play in deregulating cellular pathways involved in these processes. we, therefore, provide an overview of the role of different microRNAs in promoting tumor metastasis and their role as potential biomarkers for the prognosis, monitoring, and diagnosis of GI cancer patients. Finally, we relate the possible use of nutraceuticals as a new strategy for targeting numerous microRNAs and different pathways involved in GI tumor invasiveness.

Lucarini, V., Nardozi, D., Angiolini, V., Benvenuto, M., Focaccetti, C., Carrano, R., et al. (2023). Tumor Microenvironment Remodeling in Gastrointestinal Cancer: Role of miRNAs as Biomarkers of Tumor Invasion. BIOMEDICINES, 11(6), 1761 [10.3390/biomedicines11061761].

Tumor Microenvironment Remodeling in Gastrointestinal Cancer: Role of miRNAs as Biomarkers of Tumor Invasion

Nardozi, D;Benvenuto, M;Focaccetti, C;Carrano, R;Bei, R;
2023-01-01

Abstract

gastrointestinal (GI) cancers are the most frequent neoplasm, responsible for half of all cancer-related deaths. Mmtastasis is the leading cause of death from GI cancer; thus, studying the processes that regulate cancer cell migration is of paramount importance for the development of new therapeutic strategies. In this review, we summarize the mechanisms adopted by cancer cells to promote cell migration and the subsequent metastasis formation by highlighting the key role that tumor microenvironment components play in deregulating cellular pathways involved in these processes. we, therefore, provide an overview of the role of different microRNAs in promoting tumor metastasis and their role as potential biomarkers for the prognosis, monitoring, and diagnosis of GI cancer patients. Finally, we relate the possible use of nutraceuticals as a new strategy for targeting numerous microRNAs and different pathways involved in GI tumor invasiveness.
2023
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore MED/04
English
gastrointestinal tumors
miRNA
biomarker
nutraceuticals
tumor microenvironment
tumor cell migration
metastasis
EMT
Lucarini, V., Nardozi, D., Angiolini, V., Benvenuto, M., Focaccetti, C., Carrano, R., et al. (2023). Tumor Microenvironment Remodeling in Gastrointestinal Cancer: Role of miRNAs as Biomarkers of Tumor Invasion. BIOMEDICINES, 11(6), 1761 [10.3390/biomedicines11061761].
Lucarini, V; Nardozi, D; Angiolini, V; Benvenuto, M; Focaccetti, C; Carrano, R; Besharat, Z; Bei, R; Masuelli, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/342543
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