The Modified Blalock Taussig Shunt (MBTS) is one of the most common palliative operations in case of cyanotic heart diseases. Thus far, the decision on the position, size, and geometry of the implant relies on clinicians' experience. In this paper, a Medical Digital Twin pipeline based on reduced order modeling is presented for fast and interactive evaluation of the hemodynamic parameters of MBTS. An infant case affected by complete pulmonary atresia was selected for this study. A three-dimensional digital model of the infant's MBTS morphology was generated. A wide spectrum of MBTS geometries was explored by introducing twelve Radial Basis Function mesh modifiers. The combination of these modifiers allowed for analysis of various MBTS shapes. The final results proved the potential of the proposed approach for the investigation of significant hemodynamic features such as velocity, pressure, and wall shear stress as a function of the shunt's morphology in real-time. In particular, it was demonstrated that the modifications of the MBTS morphology had a profound effect on the hemodynamic indices. The adoption of reduced models turned out to be a promising path to follow for MBTS numerical evaluation, with the potential to support patient-specific preoperative planning.

Kardampiki, E., Vignali, E., Haxhiademi, D., Federici, D., Ferrante, E., Porziani, S., et al. (2022). The hemodynamic effect of Modified Blalock–Taussig Shunt morphologies: a computational analysis based on reduced order modeling. ELECTRONICS, 11(13) [10.3390/electronics11131930].

The hemodynamic effect of Modified Blalock–Taussig Shunt morphologies: a computational analysis based on reduced order modeling

Porziani S.;Chiappa A.;Groth C.;Biancolini M. E.;
2022-01-01

Abstract

The Modified Blalock Taussig Shunt (MBTS) is one of the most common palliative operations in case of cyanotic heart diseases. Thus far, the decision on the position, size, and geometry of the implant relies on clinicians' experience. In this paper, a Medical Digital Twin pipeline based on reduced order modeling is presented for fast and interactive evaluation of the hemodynamic parameters of MBTS. An infant case affected by complete pulmonary atresia was selected for this study. A three-dimensional digital model of the infant's MBTS morphology was generated. A wide spectrum of MBTS geometries was explored by introducing twelve Radial Basis Function mesh modifiers. The combination of these modifiers allowed for analysis of various MBTS shapes. The final results proved the potential of the proposed approach for the investigation of significant hemodynamic features such as velocity, pressure, and wall shear stress as a function of the shunt's morphology in real-time. In particular, it was demonstrated that the modifications of the MBTS morphology had a profound effect on the hemodynamic indices. The adoption of reduced models turned out to be a promising path to follow for MBTS numerical evaluation, with the potential to support patient-specific preoperative planning.
2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore ING-IND/14
English
computational fluid dynamics
reduced order modeling
hemodynamics
Modified Blalock-Taussig Shunt
RBF mesh morphing
Medical Digital Twin
Kardampiki, E., Vignali, E., Haxhiademi, D., Federici, D., Ferrante, E., Porziani, S., et al. (2022). The hemodynamic effect of Modified Blalock–Taussig Shunt morphologies: a computational analysis based on reduced order modeling. ELECTRONICS, 11(13) [10.3390/electronics11131930].
Kardampiki, E; Vignali, E; Haxhiademi, D; Federici, D; Ferrante, E; Porziani, S; Chiappa, A; Groth, C; Cioffi, M; Biancolini, Me; Costa, E; Celi, S
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/341726
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact