The association between human immunodeficiency virus (HIV) DNA load and immunologic parameters was investigated in 163 HIV-infected patients with undetectable plasma viremia during highly active antiretroviral therapy (HAART). Patients with HIV DNA below the 25th percentile (133 copies/10(6) peripheral blood mononuclear cells) had higher pre-HAART (P = 0.001) and current (P = 0.005) CD4 counts and a prolonged duration of treatment (P 0.001). At adjusted analysis, prolonged duration of treatment was independently associated with lower (P 0.006) and undetectable (P < 0.001) HfV DNA values.

Sarmati, L., Parisi, S., Nicastri, E., D'Ettorre, G., Palmisano, L., Andreotti, M., et al. (2005). Association between cellular human immunodeficiency virus DNA level and immunological parameters in patients with undetectable plasma viremia level during highly active antiretroviral therapy. JOURNAL OF CLINICAL MICROBIOLOGY, 43(12), 6183-6185 [10.1128/JCM.43.12.6183-6185.2005].

Association between cellular human immunodeficiency virus DNA level and immunological parameters in patients with undetectable plasma viremia level during highly active antiretroviral therapy

SARMATI, LOREDANA;ANDREONI, MASSIMO
2005-01-01

Abstract

The association between human immunodeficiency virus (HIV) DNA load and immunologic parameters was investigated in 163 HIV-infected patients with undetectable plasma viremia during highly active antiretroviral therapy (HAART). Patients with HIV DNA below the 25th percentile (133 copies/10(6) peripheral blood mononuclear cells) had higher pre-HAART (P = 0.001) and current (P = 0.005) CD4 counts and a prolonged duration of treatment (P 0.001). At adjusted analysis, prolonged duration of treatment was independently associated with lower (P 0.006) and undetectable (P < 0.001) HfV DNA values.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/17 - Malattie Infettive
English
Con Impact Factor ISI
antiretrovirus agent; proteinase inhibitor; RNA directed DNA polymerase inhibitor; virus DNA; adult; article; CD4 lymphocyte count; clinical article; drug effect; drug efficacy; female; highly active antiretroviral therapy; human; Human immunodeficiency virus; Human immunodeficiency virus infection; long term care; male; nonhuman; peripheral blood mononuclear cell; priority journal; treatment duration; treatment outcome; viremia; virus load; Adult; Aged; Antiretroviral Therapy, Highly Active; DNA, Viral; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Viral Load; Viremia; DNA viruses; Human immunodeficiency virus
Sarmati, L., Parisi, S., Nicastri, E., D'Ettorre, G., Palmisano, L., Andreotti, M., et al. (2005). Association between cellular human immunodeficiency virus DNA level and immunological parameters in patients with undetectable plasma viremia level during highly active antiretroviral therapy. JOURNAL OF CLINICAL MICROBIOLOGY, 43(12), 6183-6185 [10.1128/JCM.43.12.6183-6185.2005].
Sarmati, L; Parisi, S; Nicastri, E; D'Ettorre, G; Palmisano, L; Andreotti, M; Andreoni, C; Giuliano, M; Gatti, F; Boldrin, C; Palu, G; Vullo, V; Vella, S; Andreoni, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/34143
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