We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.

Dagna, L., Broccolo, F., Paties, C., Ferrarini, M., Sarmati, L., Praderio, L., et al. (2005). A relapsing inflammatory syndrome and active human herpesvirus 8 infection. THE NEW ENGLAND JOURNAL OF MEDICINE, 353(2), 156-163 [10.1056/NEJMoa042850].

A relapsing inflammatory syndrome and active human herpesvirus 8 infection

SARMATI, LOREDANA;
2005-01-01

Abstract

We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.
2005
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/17 - MALATTIE INFETTIVE
English
Con Impact Factor ISI
adult; arthritis; article; case report; cell proliferation; clinical feature; correlation analysis; edema; female; fever; Herpes virus infection; histology; human; Human herpesvirus 8; Human immunodeficiency virus; hyperplasia; immunocompetence; Kaposi sarcoma; lymph node; lymphadenopathy; peripheral blood mononuclear cell; priority journal; rash; recurrent disease; splenomegaly; virus load; blood; isolation and purification; lymphatic system disease; middle aged; pathology; serodiagnosis; synovitis; virology; virus DNA; Arthritis; DNA, Viral; Edema; Exanthema; Female; Herpesviridae Infections; Herpesvirus 8, Human; HIV Seronegativity; Humans; Immunocompetence; Lymph Nodes; Lymphatic Diseases; Middle Aged; Recurrence; Sarcoma, Kaposi; Splenomegaly; Synovitis; Viral Load
Dagna, L., Broccolo, F., Paties, C., Ferrarini, M., Sarmati, L., Praderio, L., et al. (2005). A relapsing inflammatory syndrome and active human herpesvirus 8 infection. THE NEW ENGLAND JOURNAL OF MEDICINE, 353(2), 156-163 [10.1056/NEJMoa042850].
Dagna, L; Broccolo, F; Paties, C; Ferrarini, M; Sarmati, L; Praderio, L; Sabbadini, M; Lusso, P; Malnati, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/34140
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