We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.
Dagna, L., Broccolo, F., Paties, C.T., Ferrarini, M., Sarmati, L., Praderio, L., et al. (2005). A relapsing inflammatory syndrome and active human herpesvirus 8 infection. NEW ENGLAND JOURNAL OF MEDICINE, 353(2), 156-163.
Tipologia: | Articolo su rivista |
Citazione: | Dagna, L., Broccolo, F., Paties, C.T., Ferrarini, M., Sarmati, L., Praderio, L., et al. (2005). A relapsing inflammatory syndrome and active human herpesvirus 8 infection. NEW ENGLAND JOURNAL OF MEDICINE, 353(2), 156-163. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/17 - Malattie Infettive |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1056/NEJMoa042850 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2005 |
Titolo: | A relapsing inflammatory syndrome and active human herpesvirus 8 infection |
Autori: | |
Autori: | Dagna, L; Broccolo, F; Paties, CT; Ferrarini, M; Sarmati, L; Praderio, L; Sabbadini, MG; Lusso, P; Malnati, MS |
Appare nelle tipologie: | 01 - Articolo su rivista |