Objective: Because it has been suggested that agents acting on the gamma-aminobutyric acid-A (GABA(A)) receptor complex, such as the neuroactive steroid 3alpha,5alpha-tetrahydroprogesterone (3alpha,5alpha-THP), may be biologic modulators of aggression, we aimed to measure 3alpha,5alpha-THP plasma concentrations in subjects with schizophrenia in order to investigate a possible relation with aggressive and hostile behaviour. Methods: Eight outpatients with schizophrenia diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), were included. Aggression and hostility were assessed using the Modified Overt Aggression Scale and the paranoid/belligerence symptom cluster of the Positive and Negative Syndrome Scale. Plasma samples were obtained 1 hour before psychometric assessment and were quantified for 3alpha,5alpha-THP using a highly sensitive and specific combined analysis by gas chromatography-mass spectrometry. Results: Increased aggressiveness and hostility were associated with increased 3alpha,5alpha-THP plasma levels (Pearson r = 0.72, p = 0.043 and Pearson r = 0.72, p = 0.041, respectively). Conclusions: These preliminary results suggest that the neuroactive steroid 3alpha,5alpha-THP may affect aggression and hostility in humans.

Spalletta, G., Romeo, E., Bonaviri, G., Bernardi, G., Caltagirone, C., & Di Michele, F. (2005). Preliminary evidence for an association between aggressive and hostile behaviour and 3 alpha,5 alpha-tetrahydroprogesterone plasma levels in schizophrenia. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 30(1), 49-52.

Preliminary evidence for an association between aggressive and hostile behaviour and 3 alpha,5 alpha-tetrahydroprogesterone plasma levels in schizophrenia

ROMEO, ELENA;BERNARDI, GIORGIO;CALTAGIRONE, CARLO;
2005

Abstract

Objective: Because it has been suggested that agents acting on the gamma-aminobutyric acid-A (GABA(A)) receptor complex, such as the neuroactive steroid 3alpha,5alpha-tetrahydroprogesterone (3alpha,5alpha-THP), may be biologic modulators of aggression, we aimed to measure 3alpha,5alpha-THP plasma concentrations in subjects with schizophrenia in order to investigate a possible relation with aggressive and hostile behaviour. Methods: Eight outpatients with schizophrenia diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), were included. Aggression and hostility were assessed using the Modified Overt Aggression Scale and the paranoid/belligerence symptom cluster of the Positive and Negative Syndrome Scale. Plasma samples were obtained 1 hour before psychometric assessment and were quantified for 3alpha,5alpha-THP using a highly sensitive and specific combined analysis by gas chromatography-mass spectrometry. Results: Increased aggressiveness and hostility were associated with increased 3alpha,5alpha-THP plasma levels (Pearson r = 0.72, p = 0.043 and Pearson r = 0.72, p = 0.041, respectively). Conclusions: These preliminary results suggest that the neuroactive steroid 3alpha,5alpha-THP may affect aggression and hostility in humans.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/09
English
Con Impact Factor ISI
aggression; hostility; neuroactive steroids; schizophrenia; 3 alpha,5 alpha-tetrahydroprogesterone
WOS:000225887100008
Spalletta, G., Romeo, E., Bonaviri, G., Bernardi, G., Caltagirone, C., & Di Michele, F. (2005). Preliminary evidence for an association between aggressive and hostile behaviour and 3 alpha,5 alpha-tetrahydroprogesterone plasma levels in schizophrenia. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 30(1), 49-52.
Spalletta, G; Romeo, E; Bonaviri, G; Bernardi, G; Caltagirone, C; Di Michele, F
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/34128
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact