Synthetic antigen-conjugated DNA systems for antibody detection and characterization

Antibodies are among the most relevant biomolecular targetsfordiagnostic and clinical applications. In this Perspective, we providea critical overview of recent research efforts focused on the developmentand characterization of devices, switches, and reactions based onthe use of synthetic antigen-conjugated DNA strands designed to beresponsive to specific antibodies. These systems can find applicationsin sensing, drug-delivery, and antibody-antigen binding characterization.The examples described here demonstrate how the programmability andchemical versatility of synthetic nucleic acids can be used to createinnovative analytical tools and target-responsive systems with promisingpotentials.