The long pentraxin 3 (PTX3) is member of a complex superfamily of multifunctional proteins characterized by a cyclic multimeric structure. PTX3 is highly conserved in evolution and is produced by innate-immunity cells in response to proinflammatory signals and Toll-like receptor engagement. PTX3 plays complex, nonredundant functions in vivo, acting as a predecessor of antibodies, recognizing microbes, activating complement, facilitating pathogen recognition by phagocytes, and hence, playing a nonredundant role in resistance against selected pathogens. In addition, PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility.

Bottazzi, B., Bastone, A., Doni, A., Garlanda, C., Valentino, S., Deban, L., et al. (2006). The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility. JOURNAL OF LEUKOCYTE BIOLOGY, 79(5), 909-912 [10.1189/jlb.1005557].

The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility

SALUSTRI, ANTONIETTA;
2006-05-01

Abstract

The long pentraxin 3 (PTX3) is member of a complex superfamily of multifunctional proteins characterized by a cyclic multimeric structure. PTX3 is highly conserved in evolution and is produced by innate-immunity cells in response to proinflammatory signals and Toll-like receptor engagement. PTX3 plays complex, nonredundant functions in vivo, acting as a predecessor of antibodies, recognizing microbes, activating complement, facilitating pathogen recognition by phagocytes, and hence, playing a nonredundant role in resistance against selected pathogens. In addition, PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/17
English
Animals; Fertility; Serum Amyloid P-Component; Humans; Immunity, Innate; Evolution, Molecular; C-Reactive Protein; Inflammation; Extracellular Matrix; Ovarian Follicle; Cardiovascular Diseases; Biological Markers; Female
Bottazzi, B., Bastone, A., Doni, A., Garlanda, C., Valentino, S., Deban, L., et al. (2006). The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility. JOURNAL OF LEUKOCYTE BIOLOGY, 79(5), 909-912 [10.1189/jlb.1005557].
Bottazzi, B; Bastone, A; Doni, A; Garlanda, C; Valentino, S; Deban, L; Maina, V; Cotena, A; Moalli, F; Vago, L; Salustri, A; Romani, L; Mantovani, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/33945
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