We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.
Mariotti, B., Meconi, F., Palmieri, R., De Bellis, E., Lavorgna, S., Ottone, T., et al. (2019). Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations. CASE REPORTS IN HEMATOLOGY, 2019, 4 [10.1155/2019/6707506].
Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
Mariotti, Benedetta;Meconi, Federico;Palmieri, Raffaele;De Bellis, Eleonora;Lavorgna, Serena;Ottone, Tiziana;Lo-Coco, Francesco;Cicconi, Laura
2019-01-01
Abstract
We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.| File | Dimensione | Formato | |
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Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations.pdf
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