Psoriasis affects about 2-3% of the Caucasian population. Biologics such as infliximab, etanercept, adalimumab and ustekinumab are efficacious treatments of plaque-type psoriasis. Critical to monitoring drug efficacy and safety is availability of long-term data. Despite the chronic nature of psoriasis, to date limited long-term clinical data have been available, as challenges are inherent in conducting a long-term analysis. With increasing time, it is more likely that the number of patients discontinuing treatment will also increase, due to loss of efficacy, adverse events or loss to follow-up. Interpretation of these data becomes confounded when one must consider missing data. Several approaches to analysing long-term data exist, and each accounts for missing data differently.

Papoutsaki, M., Talamonti, M., Giunta, A., Costanzo, A., Ruzzetti, M., Teoli, M., et al. (2010). The impact of methodological approaches for presenting long-term clinical data on estimates of efficacy in psoriasis illustrated by three-year treatment data on infliximab. DERMATOLOGY, 221 Suppl 1, 43-47 [10.1159/000316184].

The impact of methodological approaches for presenting long-term clinical data on estimates of efficacy in psoriasis illustrated by three-year treatment data on infliximab

Talamonti, M;Giunta, A;COSTANZO, ANTONIO;CHIMENTI, SERGIO
2010

Abstract

Psoriasis affects about 2-3% of the Caucasian population. Biologics such as infliximab, etanercept, adalimumab and ustekinumab are efficacious treatments of plaque-type psoriasis. Critical to monitoring drug efficacy and safety is availability of long-term data. Despite the chronic nature of psoriasis, to date limited long-term clinical data have been available, as challenges are inherent in conducting a long-term analysis. With increasing time, it is more likely that the number of patients discontinuing treatment will also increase, due to loss of efficacy, adverse events or loss to follow-up. Interpretation of these data becomes confounded when one must consider missing data. Several approaches to analysing long-term data exist, and each accounts for missing data differently.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/35 - Malattie Cutanee e Veneree
eng
Con Impact Factor ISI
Data Interpretation, Statistical; Aged, 80 and over; Male; Treatment Outcome; Middle Aged; Female; Dermatologic Agents; Humans; Psoriasis; Longitudinal Studies; Aged; Adult; Antibodies, Monoclonal
Papoutsaki, M., Talamonti, M., Giunta, A., Costanzo, A., Ruzzetti, M., Teoli, M., et al. (2010). The impact of methodological approaches for presenting long-term clinical data on estimates of efficacy in psoriasis illustrated by three-year treatment data on infliximab. DERMATOLOGY, 221 Suppl 1, 43-47 [10.1159/000316184].
Papoutsaki, M; Talamonti, M; Giunta, A; Costanzo, A; Ruzzetti, M; Teoli, M; Chimenti, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/33746
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