The lipid second messenger ceramide, which is generated by acidic and neutral sphingomyelinases or ceramide synthases, is a common intermediate of many apoptotic pathways. Metabolism of ceramide involves several enzymes, including glucosylceramide synthase and GD3 synthase, and results in the formation of gangliosides (GM3, GD3, and GT3), which in turn promote the generation of reactive oxygen species (ROS) and apoptosis. Fenretinide, a retinoic acid derivative, is thought to induce apoptosis via increases in ceramide levels, but the link between ceramide and subsequent apoptosis in neuroblastoma cells is unclear.

Lovat, P., DI SANO, F., Corazzari, M., Fazi, B., Donnorso, R., Pearson, A., et al. (2004). Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 96(17), 1288-1299 [10.1093/jnci/djh254].

Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide

DI SANO, FEDERICA;CORAZZARI, MARCO;FAZI, BARBARA;PIACENTINI, MAURO
2004-09-01

Abstract

The lipid second messenger ceramide, which is generated by acidic and neutral sphingomyelinases or ceramide synthases, is a common intermediate of many apoptotic pathways. Metabolism of ceramide involves several enzymes, including glucosylceramide synthase and GD3 synthase, and results in the formation of gangliosides (GM3, GD3, and GT3), which in turn promote the generation of reactive oxygen species (ROS) and apoptosis. Fenretinide, a retinoic acid derivative, is thought to induce apoptosis via increases in ceramide levels, but the link between ceramide and subsequent apoptosis in neuroblastoma cells is unclear.
1-set-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Morpholines; Fumonisins; Apoptosis; Glucosyltransferases; Antineoplastic Agents; Enzyme Activation; Humans; Ceramides; Cell Line, Tumor; Enzyme Inhibitors; RNA, Small Interfering; Gangliosides; Reactive Oxygen Species; Desipramine; Sphingomyelin Phosphodiesterase; Neuroblastoma; Gene Expression Regulation, Neoplastic; Arachidonate 12-Lipoxygenase; Flow Cytometry; Fenretinide; Oxidoreductases
Lovat, P., DI SANO, F., Corazzari, M., Fazi, B., Donnorso, R., Pearson, A., et al. (2004). Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 96(17), 1288-1299 [10.1093/jnci/djh254].
Lovat, P; DI SANO, F; Corazzari, M; Fazi, B; Donnorso, R; Pearson, A; Hall, A; Redfern, C; Piacentini, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/33036
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