The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.

Diomedi, M., Sallustio, F., Rizzato, B., Ferrante, F., Leone, G., Spera, E., et al. (2005). Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study. NEUROLOGY, 65(6), 919-921 [10.1212/01.wnl.0000173835.12308.bb].

Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

DIOMEDI, MARINA;SPERA, ENRICO;BERNARDI, GIORGIO
2005-05

Abstract

The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - Neurologia
English
Con Impact Factor ISI
placebo; sildenafil; article; blood flow velocity; blood vessel reactivity; brain blood vessel; breath holding; clinical article; clinical trial; controlled clinical trial; controlled study; Doppler echography; double blind procedure; drug mechanism; erectile dysfunction; headache; hemodynamics; human; male; migraine; priority journal; pulse wave; randomized controlled trial; Aged; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Double-Blind Method; Endothelial Cells; Humans; Male; Middle Aged; Migraine Disorders; Phosphodiesterase Inhibitors; Piperazines; Placebos; Time Factors; Ultrasonography, Doppler, Transcranial; Vasodilation
Diomedi, M., Sallustio, F., Rizzato, B., Ferrante, F., Leone, G., Spera, E., et al. (2005). Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study. NEUROLOGY, 65(6), 919-921 [10.1212/01.wnl.0000173835.12308.bb].
Diomedi, M; Sallustio, F; Rizzato, B; Ferrante, F; Leone, G; Spera, E; Scarfini, M; Bernardi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/32832
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