We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.

Camarda, R., Camarda, C., Monastero, R., Grimaldi, S., Camarda, L., Pipia, C., et al. (2007). Movements execution in amnestic mild cognitive impairment and Alzheimer's disease. BEHAVIOURAL NEUROLOGY, 18(3), 135-142.

Movements execution in amnestic mild cognitive impairment and Alzheimer's disease

CALTAGIRONE, CARLO;
2007-01-01

Abstract

We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.
2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Severity of Illness Index; Humans; Alzheimer Disease; Aged; Mental Recall; Cognition Disorders; Demography; Movement Disorders; Neuropsychological Tests; Amnesia; Biomechanics; Female; Male; Reaction Time
PMID: 17726241
Camarda, R., Camarda, C., Monastero, R., Grimaldi, S., Camarda, L., Pipia, C., et al. (2007). Movements execution in amnestic mild cognitive impairment and Alzheimer's disease. BEHAVIOURAL NEUROLOGY, 18(3), 135-142.
Camarda, R; Camarda, C; Monastero, R; Grimaldi, S; Camarda, L; Pipia, C; Caltagirone, C; Gangitano, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/32771
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