Inflammation has been extensively implicated in the pathogenesis of Alzheimer's disease (AD). Although there is evidence of a key role for cytokines in neuroinflammation processes, so far the proinflammatory cytokine interleukin (IL)-18 has not been associated with AD. The aim of this study was to investigate the impact of two polymorphisms of the human IL-18 gene promoter at positions -607 (C/A) and -137 (G/C) on both susceptibility to and progression of AD.

Bossù, P., Ciaramella, A., Moro, M., Bellincampi, L., Bernardini, S., Federici, G., et al. (2007). Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, 78(8), 807-811 [10.1136/jnnp.2006.103242].

Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease

BERNARDINI, SERGIO;FEDERICI, GIORGIO;CALTAGIRONE, CARLO;
2007-08-01

Abstract

Inflammation has been extensively implicated in the pathogenesis of Alzheimer's disease (AD). Although there is evidence of a key role for cytokines in neuroinflammation processes, so far the proinflammatory cytokine interleukin (IL)-18 has not been associated with AD. The aim of this study was to investigate the impact of two polymorphisms of the human IL-18 gene promoter at positions -607 (C/A) and -137 (G/C) on both susceptibility to and progression of AD.
ago-2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Polymorphism, Genetic; Humans; Alzheimer Disease; Prognosis; Aged; Cognition Disorders; Genotype; Promoter Regions, Genetic; Aged, 80 and over; Case-Control Studies; Interleukin-18; Genetic Predisposition to Disease; Female; Male
Bossù, P., Ciaramella, A., Moro, M., Bellincampi, L., Bernardini, S., Federici, G., et al. (2007). Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, 78(8), 807-811 [10.1136/jnnp.2006.103242].
Bossù, P; Ciaramella, A; Moro, M; Bellincampi, L; Bernardini, S; Federici, G; Trequattrini, A; Macciardi, F; Spoletini, I; Di Iulio, F; Caltagirone, C; Spalletta, G
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/32747
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 48
social impact