RACK1 has been shown to interact with several proteins, this suggesting that it may play a central role in cell growth regulation. Some recent articles have described RACK1 as a component of the small ribosomal subunit. To investigate the relationship between RACK1 and ribosome, we analyzed RACK1 mRNA structure and regulation. Translational regulation was studied in HeLa cells subjected to serum or amino acid deprivation and stimulation. The results show that RACK1 mRNA has a 5' terminal oligopyrimidine sequence and that its translation is dependent on the availability of serum and amino acids in exactly the same way as any other vertebrate ribosomal protein mRNA. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Loreni, F., Iadevaia, V., Tino, E., Caldarola, S., & Amaldi, F. (2005). RACK1 mRNA translation is regulated via a rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis. FEBS LETTERS, 579(25), 5517-5520 [10.1016/j.febslet.2005.09.016].

RACK1 mRNA translation is regulated via a rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis

LORENI, FABRIZIO;CALDAROLA, SARA;AMALDI, FRANCESCO
2005

Abstract

RACK1 has been shown to interact with several proteins, this suggesting that it may play a central role in cell growth regulation. Some recent articles have described RACK1 as a component of the small ribosomal subunit. To investigate the relationship between RACK1 and ribosome, we analyzed RACK1 mRNA structure and regulation. Translational regulation was studied in HeLa cells subjected to serum or amino acid deprivation and stimulation. The results show that RACK1 mRNA has a 5' terminal oligopyrimidine sequence and that its translation is dependent on the availability of serum and amino acids in exactly the same way as any other vertebrate ribosomal protein mRNA. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/11
English
Con Impact Factor ISI
Growth control; Ribosome; TOP mRNA; Translational regulation
Loreni, F., Iadevaia, V., Tino, E., Caldarola, S., & Amaldi, F. (2005). RACK1 mRNA translation is regulated via a rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis. FEBS LETTERS, 579(25), 5517-5520 [10.1016/j.febslet.2005.09.016].
Loreni, F; Iadevaia, V; Tino, E; Caldarola, S; Amaldi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/32480
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