Several studies have highlighted the key role of chronic inflammation in breast cancer development, progression, metastasis, and therapeutic outcome. These processes are mediated through a variety of cytokines and hormones that exert their biological actions either locally or distantly via systemic circulation. Recent findings suggest that positive psychosocial experiences, including psychotherapeutic interventions and therapeutic mind-body protocols, can modulate the inflammatory response by reducing the expression of genes/proteins associated with inflammation and stress-related pathways. Our preliminary results indicate that a specific mind-body therapy (MBT-T) could induce a significant reduction of the release of different cytokines and chemokines, such as SCGF , SDF-1 , MCP3, GRO , LIF, and IL-18, in the sera of breast cancer patients compared to a control group, suggesting that MBT-T could represent a promising approach to improve the wellness and outcome of breast cancer patients.

Cozzolino, M., Cocco, S., Piezzo, M., Celia, G., Costantini, S., Abate, V., et al. (2021). A Psychosocial Genomics Pilot Study in Oncology for Verifying Clinical, Inflammatory and Psychological Effects of Mind-Body Transformations-Therapy (MBT-T) in Breast Cancer Patients: Preliminary Results. JOURNAL OF CLINICAL MEDICINE, 10, 1-14 [10.3390/jcm10010136].

A Psychosocial Genomics Pilot Study in Oncology for Verifying Clinical, Inflammatory and Psychological Effects of Mind-Body Transformations-Therapy (MBT-T) in Breast Cancer Patients: Preliminary Results

Cavicchiolo E.;
2021-01-01

Abstract

Several studies have highlighted the key role of chronic inflammation in breast cancer development, progression, metastasis, and therapeutic outcome. These processes are mediated through a variety of cytokines and hormones that exert their biological actions either locally or distantly via systemic circulation. Recent findings suggest that positive psychosocial experiences, including psychotherapeutic interventions and therapeutic mind-body protocols, can modulate the inflammatory response by reducing the expression of genes/proteins associated with inflammation and stress-related pathways. Our preliminary results indicate that a specific mind-body therapy (MBT-T) could induce a significant reduction of the release of different cytokines and chemokines, such as SCGF , SDF-1 , MCP3, GRO , LIF, and IL-18, in the sera of breast cancer patients compared to a control group, suggesting that MBT-T could represent a promising approach to improve the wellness and outcome of breast cancer patients.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore M-PSI/03 - PSICOMETRIA
English
breast cancer
mind-body transformations therapy (MBT-T)
inflammation
cytokines
psychosocial genomics
Cozzolino, M., Cocco, S., Piezzo, M., Celia, G., Costantini, S., Abate, V., et al. (2021). A Psychosocial Genomics Pilot Study in Oncology for Verifying Clinical, Inflammatory and Psychological Effects of Mind-Body Transformations-Therapy (MBT-T) in Breast Cancer Patients: Preliminary Results. JOURNAL OF CLINICAL MEDICINE, 10, 1-14 [10.3390/jcm10010136].
Cozzolino, M; Cocco, S; Piezzo, M; Celia, G; Costantini, S; Abate, V; Capone, F; Barberio, D; Girelli, L; Cavicchiolo, E; Ascierto, Pa; Madonna, G; Ba...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/324486
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