Cerebral ischemia causes blood flow derangements characterized by hyperemia (increased cerebral blood flow, CBF) and subsequent hypoperfusion (decreased CBF) We previously demonstrated that protein kinase C delta (delta PKC) plays an important role in hippocampal neuronal death after ischemia However whether part of this protection is due to the role of delta PKC on CBF following cerebral ischemia remains poorly understood We hypothesized that delta PKC exacerbates hyperemia and subsequent hypoperfusion resulting in CBF derangements following ischemia Sprague Dawley (SD) rats pretreated with a delta PKC specific inhibitor (delta V1 1,05 mg/kg) exhibited attenuation of hyperemia and latent hypoperfusion characterized by vasoconstriction followed by vasodilation of microvessels after 2-vessel occlusion plus hypotension measured by 2 photon microscopy In an asphyxial cardiac arrest model (ACA), SD rats treated with delta V1 1 (pre- and post-ischemia) exhibited improved perfusion after 24 h and less hippocampal CA1 neuronal death 7 days after ACA These results suggest possible therapeutic potential of delta PKC in modulating CBF and neuronal damage after cerebral ischemia (C) 2010 IBRO Published by Elsevier Ltd All rights reserved
Lin, H.w., Defazio, R.a., Della Morte, D., Thompson, J.w., Narayanan, S.v., Raval, A.p., et al. (2010). Derangements of post-ischemic cerebral blood flow by protein kinase C delta. NEUROSCIENCE, 171(2), 566-576 [10.1016/j.neuroscience.2010.08.058].
Derangements of post-ischemic cerebral blood flow by protein kinase C delta
Della Morte, D;
2010-12-01
Abstract
Cerebral ischemia causes blood flow derangements characterized by hyperemia (increased cerebral blood flow, CBF) and subsequent hypoperfusion (decreased CBF) We previously demonstrated that protein kinase C delta (delta PKC) plays an important role in hippocampal neuronal death after ischemia However whether part of this protection is due to the role of delta PKC on CBF following cerebral ischemia remains poorly understood We hypothesized that delta PKC exacerbates hyperemia and subsequent hypoperfusion resulting in CBF derangements following ischemia Sprague Dawley (SD) rats pretreated with a delta PKC specific inhibitor (delta V1 1,05 mg/kg) exhibited attenuation of hyperemia and latent hypoperfusion characterized by vasoconstriction followed by vasodilation of microvessels after 2-vessel occlusion plus hypotension measured by 2 photon microscopy In an asphyxial cardiac arrest model (ACA), SD rats treated with delta V1 1 (pre- and post-ischemia) exhibited improved perfusion after 24 h and less hippocampal CA1 neuronal death 7 days after ACA These results suggest possible therapeutic potential of delta PKC in modulating CBF and neuronal damage after cerebral ischemia (C) 2010 IBRO Published by Elsevier Ltd All rights reserved| File | Dimensione | Formato | |
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